NOLC1 and E2F4

Number of citations of the paper that reports this interaction (PMID 8657117)
101

Data Source:
HPRD (in vivo, in vitro)

		NOLC1	E2F4
Gene Name		nucleolar and coiled-body phosphoprotein 1	E2F transcription factor 4, p107/p130-binding
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cajal Body	Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding ATP Binding GTP Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	RRNA Processing Nucleolus Organization Cell Cycle Mitotic Nuclear Division	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B POLR1A PRKACA USP4 YWHAG YWHAQ	25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		9221	1874
HPRD ID		03864	02806
Ensembl ID		ENSG00000166197	ENSG00000205250
Uniprot IDs		Q14978	Q16254
PDB IDs			1CF7
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Gene Expression Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Nervous System Development Negative Regulation Of Protein Metabolic Process Cell Differentiation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Multicellular Organismal Development Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Intrinsic Apoptotic Signaling Pathway Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Chemotaxis DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Intracellular Transport System Development Positive Regulation Of Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Cardiac Conduction Regulation Of Proteolysis Regulation Of Binding Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Protein Phosphorylation Cell Cycle Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Mitochondrion Organization Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Potassium Ion Export RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication
Tagcloud ?			adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Difference) ?			adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Intersection) ?