RIPPLY1 and HDAC7

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RIPPLY1	HDAC7
Gene Name		ripply transcriptional repressor 1	histone deacetylase 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function		Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding 14-3-3 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Somite Specification Transcription, DNA-templated Notch Signaling Pathway Embryonic Pattern Specification Somite Rostral/caudal Axis Specification Negative Regulation Of Transcription, DNA-templated Bone Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Transcription, DNA-templated Cell-cell Junction Assembly Notch Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Pancreatitis ( 23143602)	Obesity-related traits ( 23251661) Urate levels ( 23263486)
Protein-Protein Interactions		6 interactors: HDAC7 MDFI RBPMS REL THAP1 TRAF2	26 interactors: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 SIN3A UBE2I YWHAG YWHAQ ZBTB16
Entrez ID		92129	51564
HPRD ID			09133
Ensembl ID		ENSG00000147223	ENSG00000061273
Uniprot IDs		Q0D2K3	J3KPH8 Q8WUI4
PDB IDs			3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?		NIK/NF-kappaB Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Regulation Of Protein Transport Positive Regulation Of JNK Cascade Regulation Of Establishment Of Protein Localization Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Import Into Nucleus Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Localization To Nucleus Regulation Of Metabolic Process Negative Regulation Of Neuron Death Transcription, DNA-templated Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport RNA Biosynthetic Process Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Peptidyl-lysine Deacetylation Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of RNA Biosynthetic Process	Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Histone Deacetylation Protein Deacetylation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3 Deacetylation Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Histone H3-K9 Modification System Development Regulation Of Organelle Organization Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Signaling Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Cell Communication Cellular Response To Stimulus RNA Biosynthetic Process Response To Stress Positive Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cardiovascular System Development Organelle Organization Regulation Of Gene Expression Anatomical Structure Development
Tagcloud ?			antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm
Tagcloud (Difference) ?			antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm
Tagcloud (Intersection) ?