RIPPLY1 and MED19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIPPLY1	MED19
Description		ripply transcriptional repressor 1	mediator complex subunit 19
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Somite Specification Embryonic Pattern Specification Somite Rostral/caudal Axis Specification Negative Regulation Of DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 28991256 29483656)
Interacting Genes		44 interacting genes: AVPI1 BEND7 CFAP58 CTNNA3 DCAF15 DIRAS2 FHL2 GRAPL GRHL3 H3-4 HAND2 HDAC7 IRAK1BP1 KRT34 MCCD1 MDFI MED19 MEOX2 NDUFB7 PATZ1 PBX4 PFDN5 PLAGL2 PRR20A PRR20B PRR20C PRR20D PRR20E PTTG2 RBPMS REL RHOH RNF144B SAPCD1 THAP1 TRAF1 TRAF2 TRAF3 USP6 VAC14 VGLL1 ZMYND12 ZNF620 ZNF784	19 interacting genes: APP DCK DHRS7B DTX2 GRB2 HLCS KANK2 MED17 MED27 MED31 MED8 MED9 MSX1 NEDD9 NFKBIA OSTF1 RADIL RIPPLY1 ZNF76
Entrez ID		92129	219541
HPRD ID			17477
Ensembl ID		ENSG00000147223	ENSG00000156603
Uniprot IDs		Q0D2K3	A0JLT2 J3KR33
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity Thioesterase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Sequence-specific DNA Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway	Positive Regulation Of Transcription Initiation By RNA Polymerase II Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Ligase Complex Transcription Coregulator Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Activity Positive Regulation Of RNA Metabolic Process Regulation Of Dendritic Spine Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Post-translational Protein Modification Notch Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Ephrin Receptor Binding Protein Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Lymphocyte Migration Nucleoplasm Guanyl-nucleotide Exchange Factor Adaptor Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Negative Regulation Of Odontoblast Differentiation Acylglycerone-phosphate Reductase (NADP+) Activity Transcription Initiation At RNA Polymerase II Promoter Negative Regulation Of Protein Localization To Nucleus
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