RIPPLY1 and GRHL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIPPLY1	GRHL3
Description		ripply transcriptional repressor 1	grainyhead like transcription factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Cytosol Cilium Actin Cytoskeleton
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Somite Specification Embryonic Pattern Specification Somite Rostral/caudal Axis Specification Negative Regulation Of DNA-templated Transcription	Establishment Of Planar Polarity Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Pattern Specification Process Ectoderm Development Central Nervous System Development Epidermis Development Gene Expression Positive Regulation Of Gene Expression Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Eyelid Development In Camera-type Eye Establishment Of Skin Barrier Cochlea Morphogenesis
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Cleft palate ( 27018472) Fasting blood insulin (BMI interaction) ( 22581228) Male-pattern baldness ( 28196072) Response to interferon beta in multiple sclerosis ( 26644207)
Interacting Genes		44 interacting genes: AVPI1 BEND7 CFAP58 CTNNA3 DCAF15 DIRAS2 FHL2 GRAPL GRHL3 H3-4 HAND2 HDAC7 IRAK1BP1 KRT34 MCCD1 MDFI MED19 MEOX2 NDUFB7 PATZ1 PBX4 PFDN5 PLAGL2 PRR20A PRR20B PRR20C PRR20D PRR20E PTTG2 RBPMS REL RHOH RNF144B SAPCD1 THAP1 TRAF1 TRAF2 TRAF3 USP6 VAC14 VGLL1 ZMYND12 ZNF620 ZNF784	8 interacting genes: EAF1 ENKD1 GRHL1 GRHL2 PRMT1 PRMT5 PRMT6 RIPPLY1
Entrez ID		92129	57822
HPRD ID			12210
Ensembl ID		ENSG00000147223	ENSG00000158055
Uniprot IDs		Q0D2K3	Q8TE85
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity Thioesterase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Sequence-specific DNA Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway	Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylosome Regulation Of DNA-templated Transcription Methyltransferase Activity Regulation Of RNA Biosynthetic Process Histone H3 Methyltransferase Activity Methyl-CpG Binding Regulation Of RNA Metabolic Process Methylation Protein Methylation Regulation Of Megakaryocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process GATOR1 Complex Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Epithelium Migration Regulation Of Gene Expression Chromatin DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Peptidyl-arginine N-methylation Histone H3R2 Methyltransferase Activity Macromolecule Methylation Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Epithelial Cell Morphogenesis Involved In Placental Branching Intronic Transcription Regulatory Region Sequence-specific DNA Binding N-methyltransferase Activity Regulation Of Macromolecule Metabolic Process Epidermis Development Anterior Neural Tube Closure Positive Regulation Of Hemoglobin Biosynthetic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Somite Specification Regulation Of Multicellular Organismal Development Nucleoplasm Chromatin Remodeling Cellular Response To Methionine Super Elongation Complex Cell-cell Junction Organization Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4 Methyltransferase Activity
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