HDAC7 and PRKD2

Number of citations of the paper that reports this interaction (PMID 15623513)
42

Data Source:
HPRD (in vitro, in vivo)

		HDAC7	PRKD2
Gene Name		histone deacetylase 7	protein kinase D2
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding 14-3-3 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Transcription, DNA-templated Cell-cell Junction Assembly Notch Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Urate levels ( 23263486)	Chronic lymphocytic leukemia ( 18758461)
Protein-Protein Interactions		26 interactors: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 SIN3A UBE2I YWHAG YWHAQ ZBTB16	17 interactors: CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2
Entrez ID		51564	25865
HPRD ID		09133	09523
Ensembl ID		ENSG00000061273	ENSG00000105287
Uniprot IDs		J3KPH8 Q8WUI4	M0QZW1 M0R2R2 Q8NCK8 Q9BZL6
PDB IDs		3C0Y 3C0Z 3C10 3ZNR 3ZNS	2COA 3BGM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Histone Deacetylation Protein Deacetylation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3 Deacetylation Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Histone H3-K9 Modification System Development Regulation Of Organelle Organization Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Signaling Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Cell Communication Cellular Response To Stimulus RNA Biosynthetic Process Response To Stress Positive Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cardiovascular System Development Organelle Organization Regulation Of Gene Expression Anatomical Structure Development	Positive Regulation Of Gene Expression Regulation Of Osteoblast Differentiation Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Chamber Development Developmental Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Steroid Hormone Stimulus Multicellular Organismal Development Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Intracellular Receptor Signaling Pathway Heart Development Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Glandular Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Transcription, DNA-templated Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Ossification Regulation Of RNA Metabolic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Positive Regulation Of Osteoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Cell Differentiation Muscle Cell Differentiation Negative Regulation Of Gene Expression Muscle Tissue Development Negative Regulation Of Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Cardiac Septum Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Vasculogenesis Positive Regulation Of Ossification
Tagcloud ?		antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm	a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Difference) ?		antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm	a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Intersection) ?