HDAC7 and ESM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HDAC7	ESM1
Description		histone deacetylase 7	endothelial cell specific molecule 1
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Matrix
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity SUMO Transferase Activity Protein Kinase Binding Protein Lysine Deacetylase Activity Metal Ion Binding 14-3-3 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Hepatocyte Growth Factor Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Chromatin Organization Protein Deacetylation Cell-cell Junction Assembly Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Negative Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of MRNA Processing Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Membraneless Organelle Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Angiogenesis Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Valproic acid Decitabine Vorinostat Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Cocaine dependence ( 31212010) Familial squamous cell lung carcinoma ( 29924316) Sense of smell ( 26632684) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRABD2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 MTCL2 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 UBC UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16	16 interacting genes: ADAM12 ANKS1A AQP1 BANP CTNNB1 FAM124B FRS3 HDAC7 HOXA1 ITGB2 MEOX2 NRF1 NUFIP2 PRKAB2 VGLL3 YY1
Entrez ID		51564	11082
HPRD ID		09133	03310
Ensembl ID		ENSG00000061273	ENSG00000164283
Uniprot IDs		Q8WUI4	Q9NQ30
PDB IDs		3C0Y 3C0Z 3C10 3ZNR 3ZNS 8Q9Q
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Protein Lysine Deacetylase Activity Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Chromatin Binding Histone Deacetylase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Protein Lysine Delactylase Activity Negative Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Motility Regulation Of Striated Muscle Cell Differentiation Transcription Corepressor Binding Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Migration Regulation Of Cell Differentiation Regulation Of Gene Expression Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Signal Transduction	Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Vasculature Development Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Glomerulus Vasculature Development Regulation Of Angiogenesis Eye Morphogenesis Epithelium Development Camera-type Eye Morphogenesis Nitric Oxide Transmembrane Transporter Activity Vasculature Development Metanephric Proximal Convoluted Tubule Segment 2 Development Ephrin Receptor Binding Glycerol Transmembrane Transporter Activity Corticotropin Secretion Mesenchymal Stem Cell Differentiation Nucleoplasm Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Embryonic Pattern Specification Vasculogenesis SMAD Binding Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Protein Kinase Binding Renal Outer Medulla Development Renal Vesicle Formation Fibroblast Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development DNA-binding Transcription Factor Binding Limb Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Regulation Of Cell Migration Involved In Sprouting Angiogenesis Immunoglobulin Heavy Chain V-D-J Recombination Sensory Organ Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Saliva Secretion Nucleus
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