RIPPLY1 and DIRAS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIPPLY1	DIRAS2
Description		ripply transcriptional repressor 1	DIRAS family GTPase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Somite Specification Embryonic Pattern Specification Somite Rostral/caudal Axis Specification Negative Regulation Of DNA-templated Transcription	Signal Transduction Positive Regulation Of MAP Kinase Activity
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Cognitive test performance ( 17903297) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Multiple sclerosis ( 31604244) Protein quantitative trait loci ( 18464913)
Interacting Genes		44 interacting genes: AVPI1 BEND7 CFAP58 CTNNA3 DCAF15 DIRAS2 FHL2 GRAPL GRHL3 H3-4 HAND2 HDAC7 IRAK1BP1 KRT34 MCCD1 MDFI MED19 MEOX2 NDUFB7 PATZ1 PBX4 PFDN5 PLAGL2 PRR20A PRR20B PRR20C PRR20D PRR20E PTTG2 RBPMS REL RHOH RNF144B SAPCD1 THAP1 TRAF1 TRAF2 TRAF3 USP6 VAC14 VGLL1 ZMYND12 ZNF620 ZNF784	2 interacting genes: RIPPLY1 UNC45A
Entrez ID		92129	54769
HPRD ID			09711
Ensembl ID		ENSG00000147223	ENSG00000165023
Uniprot IDs		Q0D2K3	Q96HU8
PDB IDs			2ERX 6NAZ
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity Thioesterase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Sequence-specific DNA Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway	Somite Rostral/caudal Axis Specification Somite Specification Segment Specification Hsp90 Protein Binding Anterior/posterior Axis Specification Embryonic Axis Specification
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