HDAC7 and BRWD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HDAC7	BRWD1
Description		histone deacetylase 7	bromodomain and WD repeat domain containing 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Cell Projection Ciliary Membrane
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity SUMO Transferase Activity Protein Kinase Binding Protein Lysine Deacetylase Activity Metal Ion Binding 14-3-3 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Chromatin Organization Protein Deacetylation Cell-cell Junction Assembly Negative Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Negative Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of MRNA Processing Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Membraneless Organelle Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription	Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
Drugs		Valproic acid Decitabine Vorinostat Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Smoking initiation ( 33082346) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)
Interacting Genes		59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRABD2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 MTCL2 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 UBC UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16	18 interacting genes: APP APPL1 CALM1 COPS5 CUL4B FNDC3B HDAC7 HIVEP2 NRF1 NUTF2 PPP5C SMARCA4 SMARCD1 STAT3 SYT4 TAF1 TRIM55 TRIM63
Entrez ID		51564	54014
HPRD ID		09133	11683
Ensembl ID		ENSG00000061273	ENSG00000185658
Uniprot IDs		Q8WUI4	Q9NSI6
PDB IDs		3C0Y 3C0Z 3C10 3ZNR 3ZNS 8Q9Q	3Q2E
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Protein Lysine Deacetylase Activity Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Chromatin Binding Histone Deacetylase Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Protein Lysine Delactylase Activity Negative Regulation Of Macromolecule Metabolic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Motility Regulation Of Striated Muscle Cell Differentiation Transcription Corepressor Binding Positive Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Migration Regulation Of Cell Differentiation Regulation Of Gene Expression Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Signal Transduction	Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Astrocyte Projection Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Cycle Process Titin Binding Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway NBAF Complex RSC-type Complex NpBAF Complex Regulation Of Cell Cycle Phase Transition GBAF Complex Protein Modification By Small Protein Conjugation Response To Lead Ion Modulation Of Chemical Synaptic Transmission Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleosome Disassembly Negative Regulation Of Glycolytic Process Epigenetic Regulation Of Gene Expression Neuronal Dense Core Vesicle Protein-DNA Complex Disassembly Post-translational Protein Modification Regulation Of Cellular Response To Stress Protein Import Into Nucleus Negative Regulation Of ATP Metabolic Process Regulation Of Endocytosis Nucleoplasm Import Into Nucleus Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process
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