HDAC7 and MEF2A

Number of citations of the paper that reports this interaction (PMID 16956611)
11

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		HDAC7	MEF2A
Gene Name		histone deacetylase 7	myocyte enhancer factor 2A
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Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding 14-3-3 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Transcription, DNA-templated Cell-cell Junction Assembly Notch Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Mitochondrial Genome Maintenance Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Urate levels ( 23263486)
Protein-Protein Interactions		26 interactors: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 SIN3A UBE2I YWHAG YWHAQ ZBTB16	26 interactors: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 EP300 ERBB2IP HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		51564	4205
HPRD ID		09133	02807
Ensembl ID		ENSG00000061273	ENSG00000068305
Uniprot IDs		J3KPH8 Q8WUI4	Q02078
PDB IDs		3C0Y 3C0Z 3C10 3ZNR 3ZNS	1C7U 1EGW 1LEW 3KOV 3MU6 3P57
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Histone Deacetylation Protein Deacetylation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3 Deacetylation Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Histone H3-K9 Modification System Development Regulation Of Organelle Organization Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Signaling Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Cell Communication Cellular Response To Stimulus RNA Biosynthetic Process Response To Stress Positive Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cardiovascular System Development Organelle Organization Regulation Of Gene Expression Anatomical Structure Development	Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Skeletal Muscle Tissue Development Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Tissue Development Response To Organic Substance Regulation Of Cell Development Cardiovascular System Development Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Skeletal Muscle Tissue Development System Development Cellular Macromolecule Biosynthetic Process Developmental Process
Tagcloud ?		antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Difference) ?		antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Intersection) ?