HDAC7 and EDNRA

Number of citations of the paper that reports this interaction (PMID 11262386)
12

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		HDAC7	EDNRA
Gene Name		histone deacetylase 7	endothelin receptor type A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane T-tubule Nuclear Membrane Membrane Raft
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding 14-3-3 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Transcription, DNA-templated Cell-cell Junction Assembly Notch Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Patterning Of Blood Vessels Response To Hypoxia In Utero Embryonic Development Histamine Secretion Positive Regulation Of Protein Phosphorylation Glomerular Filtration Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Heart Development Aging Respiratory Gaseous Exchange Metabolic Process Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Cell Proliferation Neural Crest Cell Development Artery Smooth Muscle Contraction Glucose Transport Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Vasoconstriction Positive Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Penile Erection Response To Morphine Fibroblast Proliferation Enteric Nervous System Development Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Maternal Process Involved In Parturition Head Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Kidney Development
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Bosentan 2-HYDROXY-3,5-DIIODOBENZOIC ACID Sitaxentan
Diseases
GWAS		Obesity-related traits ( 23251661) Urate levels ( 23263486)	Carotid intima media thickness ( 21909108) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Obesity-related traits ( 23251661)
Protein-Protein Interactions		26 interactors: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 SIN3A UBE2I YWHAG YWHAQ ZBTB16	7 interactors: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		51564	1909
HPRD ID		09133	00571
Ensembl ID		ENSG00000061273	ENSG00000151617
Uniprot IDs		J3KPH8 Q8WUI4	P25101
PDB IDs		3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Histone Deacetylation Protein Deacetylation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3 Deacetylation Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Histone H3-K9 Modification System Development Regulation Of Organelle Organization Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Signaling Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Cell Communication Cellular Response To Stimulus RNA Biosynthetic Process Response To Stress Positive Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cardiovascular System Development Organelle Organization Regulation Of Gene Expression Anatomical Structure Development	Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Developmental Pigmentation Cell Activation Signal Transduction Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Heart Contraction Cell Surface Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Vasoconstriction Signaling Cell Communication Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Smooth Muscle Contraction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Developmental Pigmentation Peptide Hormone Secretion Neural Crest Cell Development Positive Regulation Of Leukocyte Chemotaxis Peptide Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Neural Crest Cell Differentiation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Protein Kinase Activity Hormone Secretion Positive Regulation Of Leukocyte Migration Regulation Of CAMP Biosynthetic Process Positive Regulation Of Kinase Activity Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Protein Kinase C Deactivation Negative Regulation Of Biosynthetic Process Hormone Transport
Tagcloud ?		antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm	aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization
Tagcloud (Difference) ?		antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm	aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization
Tagcloud (Intersection) ?