MAGI2

Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Tight Junction Postsynaptic Density Dendrite Slit Diaphragm Protein Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Protein Binding Phosphatase Binding Receptor Signaling Complex Scaffold Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Protein Heterooligomerization Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus
Pathways		Nephrin interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Hippocampal atrophy ( 19668339) Obesity-related traits ( 23251661) Response to antidepressant treatment ( 22041458)
Protein-protein Interactions		15 interactors: ACVR2A ADRB1 ARRDC3 ATN1 BAI1 CTNNB1 CTNND2 DLL1 DSCAML1 GRID2 PLXNB3 PTEN RAPGEF2 SMAD3 TGFA
Entrez ID		9863
HPRD ID		16212
Ensembl ID		ENSG00000187391
Uniprot IDs		Q86UL8
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Developmental Process Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis System Development Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Generation Of Neurons Regulation Of Cell Differentiation Organ Development Nervous System Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Neuron Differentiation Embryonic Skeletal System Development Signal Transduction Cell Fate Determination Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Junction Assembly Signaling Regulation Of Cellular Component Organization Pattern Specification Process Cell Communication Cardiovascular System Development Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Negative Regulation Of Dendrite Morphogenesis Regulation Of Apoptotic Process Regulation Of Postsynaptic Membrane Potential Anterior/posterior Pattern Specification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Embryonic Heart Tube Development Central Nervous System Development Embryonic Pattern Specification Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Ossification
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28