MAGI2

Name	membrane associated guanylate kinase, WW and PDZ domain containing 2
Structure
Interactors	30 interactors: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAM DSCAML1 DYRK3 GRID2 LCOR MORN4 PDZD11 PLEKHF2 PLXNB3 PRRG4 PTEN RAPGEF2 RIPK4 RPS6KA1 SMAD3 SNRPB TGFA VANGL2
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Late Endosome Centrosome Centriole Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Postsynaptic Density Membrane Dendrite Protein-containing Complex Slit Diaphragm Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Ciliary Base
	Molecular Function	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Positive Regulation Of Receptor Internalization Endocytosis Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Podocyte Development Clathrin-dependent Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways	Nephrin family interactions
GWAS	Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Airway wall thickness ( 25517131 ) Bitter beverage consumption ( 31046077 ) Body mass index ( 25673413 28892062 ) Body size at age 10 ( 32376654 ) Bronchopulmonary dysplasia ( 23897914 ) Chronotype ( 30696823 ) Computer vision syndrome ( 33941792 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) General risk tolerance (MTAG) ( 30643258 ) Hippocampal atrophy ( 19668339 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lead levels in blood ( 25820613 ) Low density lipoprotein cholesterol levels ( 33339817 ) Mammographic density (dense area) ( 25342443 ) Memory dysfunction in frontotemporal lobe dementia ( 29724592 ) Metabolite levels ( 23823483 ) Nicotine dependence ( 33144568 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Response to anti-depressant treatment in major depressive disorder ( 22041458 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Schizophrenia ( 30285260 28991256 ) Serum folate levels ( 29953918 ) Total cholesterol levels ( 33339817 ) Visceral fat ( 30942860 )
Entrez ID	9863
HPRD ID	16212
Ensembl ID	ENSG00000187391
Uniprot IDs	B7Z4H4 Q86UL8
PDB IDs	1UEP 1UEQ 1UEW 1UJV 1WFV
GO Terms Enriched among Interactors ?	PDZ Domain Binding Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Junction Assembly Synapse Synapse Organization Regulation Of Nervous System Development Chemical Synaptic Transmission Cell Junction Organization Signaling Postsynaptic Specialization Trans-synaptic Signaling Synaptic Signaling Postsynaptic Density Anchoring Junction System Development Regionalization Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Communication Anatomical Structure Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Cell-cell Junction Synapse Assembly Developmental Process Cell-cell Adhesion Mediator Activity Regulation Of Neurogenesis Glutamatergic Synapse Epithelial Tube Morphogenesis Nervous System Development Regulation Of Striated Muscle Tissue Development Cell Fate Determination Positive Regulation Of Developmental Process Pattern Specification Process Heat Generation Hepatocyte Proliferation Regulation Of Growth Regulation Of Muscle Organ Development Osteoblast Differentiation Gastrulation Embryonic Morphogenesis Animal Organ Development Positive Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cell Junction Assembly Transcription Corepressor Binding Regulation Of Multicellular Organismal Development