MAGI2 and ARRDC3

Number of citations of the paper that reports this interaction (PMID 23236378)
3

Data Source:
BioGRID (two hybrid)

		MAGI2	ARRDC3
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 2	arrestin domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Tight Junction Postsynaptic Density Dendrite Slit Diaphragm Protein Complex Synapse Perinuclear Region Of Cytoplasm	Endosome Plasma Membrane
	Molecular Function	Signal Transducer Activity Protein Binding Phosphatase Binding Receptor Signaling Complex Scaffold Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding	Protein Binding Beta-3 Adrenergic Receptor Binding
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Protein Heterooligomerization Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus	Temperature Homeostasis Negative Regulation Of Heat Generation Skin Development Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior
Pathways		Nephrin interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Hippocampal atrophy ( 19668339) Obesity-related traits ( 23251661) Response to antidepressant treatment ( 22041458)	Breast cancer (prognosis) ( 23319801) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		15 interactors: ACVR2A ADRB1 ARRDC3 ATN1 BAI1 CTNNB1 CTNND2 DLL1 DSCAML1 GRID2 PLXNB3 PTEN RAPGEF2 SMAD3 TGFA	14 interactors: BAG3 DCUN1D1 HPGDS ITCH MAGI2 MORF4L1 NEDD4 OTUB2 PDCD6IP STAM2 TNFAIP3 TRIM42 UBE2E2 WWP1
Entrez ID		9863	57561
HPRD ID		16212	09810
Ensembl ID		ENSG00000187391	ENSG00000113369
Uniprot IDs		Q86UL8	Q96B67
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Developmental Process Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis System Development Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Generation Of Neurons Regulation Of Cell Differentiation Organ Development Nervous System Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Neuron Differentiation Embryonic Skeletal System Development Signal Transduction Cell Fate Determination Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Junction Assembly Signaling Regulation Of Cellular Component Organization Pattern Specification Process Cell Communication Cardiovascular System Development Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Negative Regulation Of Dendrite Morphogenesis Regulation Of Apoptotic Process Regulation Of Postsynaptic Membrane Potential Anterior/posterior Pattern Specification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Embryonic Heart Tube Development Central Nervous System Development Embryonic Pattern Specification Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Ossification	Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Deubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Interaction With Host Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Establishment Of Protein Localization To Vacuole Cellular Protein Metabolic Process Proteolysis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Viral Life Cycle Intracellular Receptor Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Entry Into Host Cell Protein Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Type I Interferon Production Cellular Response To Stimulus Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Protein Modification Process Negative Regulation Of Leukocyte Proliferation Cellular Macromolecule Catabolic Process Regulation Of Defense Response To Virus Regulation Of Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Protein Deubiquitination
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	adrenergic arrestin arrestins basic beta2 beta2ar capable conformations consists crystal crystallization downregulation electropositive highlights ions ligases lobe lobed motifs nedd4 parallels patch portion ppxy ppyx recruit situation tail thought
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	adrenergic arrestin arrestins basic beta2 beta2ar capable conformations consists crystal crystallization downregulation electropositive highlights ions ligases lobe lobed motifs nedd4 parallels patch portion ppxy ppyx recruit situation tail thought
Tagcloud (Intersection) ?