NODAL and CRIPTO

Number of citations of the paper that reports this interaction (PubMedID 28126904)
67

Data Source:
BioGRID (pull down)

		NODAL	CRIPTO
Description		nodal growth differentiation factor	cripto, EGF-CFC family member
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Membrane Raft Side Of Membrane
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Morphogen Activity Receptor Ligand Activity Type I Activin Receptor Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Gastrulation With Mouth Forming Second Formation Of Primary Germ Layer Mesoderm Formation Trophectodermal Cell Differentiation Trophectodermal Cellular Morphogenesis Neural Fold Formation Liver Development Placenta Development Embryonic Placenta Development Maternal Placenta Development Vasculature Development Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Nervous System Development Brain Development Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Signal Transduction Polarity Specification Of Proximal/distal Axis Regulation Of Gastrulation Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Development Cell Migration Stem Cell Population Maintenance Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Floor Plate Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Heart Tube Development Endodermal Cell Differentiation Nodal Signaling Pathway Cell Migration Involved In Gastrulation Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Axial Mesodermal Cell Fate Specification Mesendoderm Development Digestive Tract Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryonic Cranial Skeleton Morphogenesis Tissue Morphogenesis Formation Of Anatomical Boundary Positive Regulation Of Epithelial Cell Proliferation Digestive System Development Embryonic Process Involved In Female Pregnancy Maternal Process Involved In Parturition Positive Regulation Of SMAD Protein Signal Transduction Left Lung Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epiblast Cell-extraembryonic Ectoderm Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade Primitive Streak Formation Apoptotic Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Stem Cell Population Maintenance Negative Regulation Of Reproductive Process	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by NODAL Regulation of signaling by NODAL	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS
Interacting Genes		6 interacting genes: ACVR1B ACVR2A ACVR2B CRIPTO KRT31 KRTAP6-3	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		4838	6997
HPRD ID		08370	01757
Ensembl ID		ENSG00000156574	ENSG00000241186
Uniprot IDs		Q96S42	F5H1T8 P13385
PDB IDs		4N1D
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ossification Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Activin Receptor Activity, Type I Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Nodal Signaling Pathway Gastrulation With Mouth Forming Second Anterior/posterior Pattern Specification Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Positive Regulation Of Erythrocyte Differentiation Regionalization Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation Regulation Of Erythrocyte Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Protein Kinase Activity Odontogenesis Positive Regulation Of Myeloid Cell Differentiation Anatomical Structure Morphogenesis Penile Erection Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Inhibin-betaglycan-ActRII Complex Nodal Binding	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cellular Response To BMP Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Response To Growth Factor Activin Receptor Activity, Type I Activin Binding Cell Surface Receptor Signaling Pathway Activin Receptor Activity Regulation Of Osteoblast Differentiation Growth Factor Binding Mesoderm Formation System Development Lung Development Mesoderm Development Animal Organ Development Regulation Of Multicellular Organismal Development Formation Of Primary Germ Layer BMP Receptor Activity Osteoblast Differentiation Outflow Tract Septum Morphogenesis Tissue Development Cardiac Septum Morphogenesis Growth Factor Activity Pattern Specification Process Heart Development Regulation Of Multicellular Organismal Process Activin Receptor Activity, Type II Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation Developmental Process Involved In Reproduction Gastrulation Gastrulation With Mouth Forming Second Cytokine Activity Heart Valve Morphogenesis
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