NODAL and ACVR2B

Number of citations: 67 (PubMedID 28126904)
Data Source: BioGRID (pull down)

		NODAL	ACVR2B
Name		nodal growth differentiation factor	activin A receptor type 2B
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Morphogen Activity Receptor Ligand Activity Type I Activin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Gastrulation With Mouth Forming Second Formation Of Primary Germ Layer Mesoderm Formation Trophectodermal Cell Differentiation Trophectodermal Cellular Morphogenesis Neural Fold Formation Liver Development Placenta Development Embryonic Placenta Development Maternal Placenta Development Vasculature Development Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Nervous System Development Brain Development Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Signal Transduction Polarity Specification Of Proximal/distal Axis Regulation Of Gastrulation Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Development Cell Migration Stem Cell Population Maintenance Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Floor Plate Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Heart Tube Development Endodermal Cell Differentiation Nodal Signaling Pathway Cell Migration Involved In Gastrulation Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Axial Mesodermal Cell Fate Specification Mesendoderm Development Digestive Tract Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryonic Cranial Skeleton Morphogenesis Tissue Morphogenesis Formation Of Anatomical Boundary Positive Regulation Of Epithelial Cell Proliferation Digestive System Development Embryonic Process Involved In Female Pregnancy Maternal Process Involved In Parturition Positive Regulation Of SMAD Protein Signal Transduction Left Lung Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epiblast Cell-extraembryonic Ectoderm Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade Primitive Streak Formation Apoptotic Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Stem Cell Population Maintenance Negative Regulation Of Reproductive Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development
Pathways		Signaling by NODAL Regulation of signaling by NODAL	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Diseases		Heterotaxy; Situs ambiguus	Heterotaxy; Situs ambiguus
GWAS		No GWAS studies recorded	Bitter beverage consumption ( 31046077 ) Body size at age 10 ( 32376654 ) Estimated glomerular filtration rate ( 31015462 31152163 ) P wave duration ( 24850809 )
Novel Interactors		None recorded	1 novel interactors: WNT5A
Interacting Genes		6 interacting genes: ACVR1B ACVR2A ACVR2B CRIPTO KRT31 KRTAP6-3	26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		4838	93
HPRD ID		08370	04106
Ensembl ID		ENSG00000156574	ENSG00000114739
Uniprot IDs		Q96S42	Q13705
PDB IDs		4N1D	2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
GO Terms Enriched among Interactors		Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ossification Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Activin Receptor Activity, Type I Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Nodal Signaling Pathway Gastrulation With Mouth Forming Second Anterior/posterior Pattern Specification Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Positive Regulation Of Erythrocyte Differentiation Regionalization Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation Regulation Of Erythrocyte Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Protein Kinase Activity Odontogenesis Positive Regulation Of Myeloid Cell Differentiation Anatomical Structure Morphogenesis Penile Erection Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Inhibin-betaglycan-ActRII Complex Nodal Binding	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation