PI4K2B and CASR

Number of citations of the paper that reports this interaction (PubMedID 11907035)
0

Data Source:
HPRD (in vivo)

		PI4K2B	CASR
Description		phosphatidylinositol 4-kinase type 2 beta	calcium sensing receptor
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Early Endosome Membrane	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse
	Molecular Function	Nucleotide Binding 1-phosphatidylinositol 4-kinase Activity ATP Binding Kinase Activity Transferase Activity	G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphate Biosynthetic Process	Ossification Response To Ischemia Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Metal Ion Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Response To Calcium Ion Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Regulation Of Presynaptic Membrane Potential Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane	G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Resveratrol	Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases			Bartter syndrome
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cannabis dependence symptom count ( 27028160) Logical memory (immediate recall) in normal cognition ( 29274321) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Calcium levels ( 20661308 20705733 24068962 29403010 25886283 25972035) Cardiac Troponin-T levels ( 23247143) Chronic widespread musculoskeletal pain ( 33331911) Clinical laboratory measurements ( 27897004) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		4 interacting genes: AKT1 CASR CD247 MAPK14	11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL
Entrez ID		55300	846
HPRD ID		15132	03122
Ensembl ID		ENSG00000038210	ENSG00000036828
Uniprot IDs		G5E9Z4 Q8TCG2	P41180
PDB IDs		4WTV 8A5X	5FBH 5FBK 5K5S 5K5T 7DTT 7DTU 7DTV 7DTW 7E6T 7E6U 7M3E 7M3F 7M3G 7M3J 7SIL 7SIM 7SIN 8SZF 8SZG 8SZH 8SZI 8WPG 8WPU 9ASB 9AVG 9AVL 9AXF 9AYF 9C1P 9C2F 9J7I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Localization Cellular Response To Peptide Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Surface Cellular Response To Lipoprotein Particle Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of D-glucose Import Response To Growth Factor Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Organ Growth Regulation Of D-glucose Import Cellular Response To Lipid Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Nutrient Levels Positive Regulation Of Fat Cell Differentiation Striated Muscle Cell Differentiation Regulation Of D-glucose Transmembrane Transport Response To Peptide RNA Stabilization Glutamatergic Synapse Positive Regulation Of Locomotion Negative Regulation Of RNA Catabolic Process Regulation Of Organ Growth Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Muscle Cell Differentiation Regulation Of TRNA Methylation Protein Homodimerization Activity Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Response To Tumor Necrosis Factor Glucose Metabolic Process Osteoblast Differentiation Response To Calcium Ion Regulation Of Fat Cell Differentiation Response To Lipid Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transport Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cellular Response To Oxygen Levels Response To Insulin-like Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Immune Response Positive Regulation Of Cell Population Proliferation Mammalian Oogenesis Stage Response To UV	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Secretion By Cell Regulation Of Secretion Protein Kinase C Signaling Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Exocytosis Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Synaptic Signaling Via Neuropeptide Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Transcription Regulator Activator Activity Mitotic Nuclear Membrane Disassembly Regulation Of Programmed Cell Death Positive Regulation Of Insulin Secretion Regulation Of Protein Secretion Regulation Of Neural Precursor Cell Proliferation Regulation Of Signal Transduction Regulation Of Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Regulation Of Cell Population Proliferation Positive Regulation Of Peptide Secretion Regulation Of Blood Vessel Endothelial Cell Migration Calyx Of Held Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Hypoxia Glandular Epithelial Cell Differentiation Cellular Response To Decreased Oxygen Levels Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Enzyme Binding Plasma Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Biomineral Tissue Development Presynaptic Cytosol Cellular Response To Oxygen Levels
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