CABLES1 and MIB1

Number of citations of the paper that reports this interaction (PubMedID 31462741)
81

Data Source:
BioGRID (proximity labelling technology)

		CABLES1	MIB1
Description		Cdk5 and Abl enzyme substrate 1	MIB E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nervous System Development Cell Division Regulation Of Cell Cycle	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis
Pathways		Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Factors involved in megakaryocyte development and platelet production	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 23563607 25282103 25429064 20881960 20189936 28552196 31562340 18391951 28270201) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Hypertriglyceridemia ( 23505323) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494 27863252) Neurofibrillary tangles ( 31497858) Platelet count ( 27863252 29403010 32888494 24026423 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Scalp hair shape ( 26926045) Sitting height ratio ( 25865494) Smoking behavior ( 19247474) Tuberculosis ( 20694014) Waist circumference ( 31928498) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 28552196 28448500 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)
Interacting Genes		8 interacting genes: ABL1 CCNA1 CCNE1 CDK3 CDK5 TDRD7 TP53 TP73	17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN
Entrez ID		91768	57534
HPRD ID		16461	06660
Ensembl ID		ENSG00000134508	ENSG00000101752
Uniprot IDs		A7K6Y5 Q8TDN4	Q86YT6
PDB IDs			4TSE 4XI6 4XI7 4XIB 8V0D 8V0E
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex P53 Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle MDM2/MDM4 Family Protein Binding Neuron Apoptotic Process Anatomical Structure Morphogenesis Organelle Organization Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Release Of Cytochrome C From Mitochondria Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Process Mismatch Repair Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Growth Negative Regulation Of Growth Kinase Activity T Cell Differentiation In Thymus Postsynaptic Density Negative Regulation Of Cell Differentiation Somitogenesis Regulation Of Cellular Senescence Cytoplasm Cerebellum Development Segmentation DNA Metabolic Process Regulation Of Cell Cycle Process Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Developmental Growth DNA Damage Response Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Senescence Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination
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