CABLES1

Description		Cdk5 and Abl enzyme substrate 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding
	Biological Process	Nervous System Development Cell Division Regulation Of Cell Cycle
Pathways		Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 23563607 25282103 25429064 20881960 20189936 28552196 31562340 18391951 28270201) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Hypertriglyceridemia ( 23505323) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494 27863252) Neurofibrillary tangles ( 31497858) Platelet count ( 27863252 29403010 32888494 24026423 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Scalp hair shape ( 26926045) Sitting height ratio ( 25865494) Smoking behavior ( 19247474) Tuberculosis ( 20694014) Waist circumference ( 31928498) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 28552196 28448500 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: MIB1
Interacting Genes		8 interacting genes: ABL1 CCNA1 CCNE1 CDK3 CDK5 TDRD7 TP53 TP73
Entrez ID		91768
HPRD ID		16461
Ensembl ID		ENSG00000134508
Uniprot IDs		A7K6Y5 Q8TDN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex P53 Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle MDM2/MDM4 Family Protein Binding Neuron Apoptotic Process Anatomical Structure Morphogenesis Organelle Organization Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Release Of Cytochrome C From Mitochondria Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Process Mismatch Repair Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Growth Negative Regulation Of Growth Kinase Activity T Cell Differentiation In Thymus Postsynaptic Density Negative Regulation Of Cell Differentiation Somitogenesis Regulation Of Cellular Senescence Cytoplasm Cerebellum Development Segmentation DNA Metabolic Process Regulation Of Cell Cycle Process Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Developmental Growth DNA Damage Response Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Senescence Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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