CABLES1 and CCNA1

Number of citations of the paper that reports this interaction (PubMedID 11733001)
0

Data Source:
HPRD (in vivo)

		CABLES1	CCNA1
Description		Cdk5 and Abl enzyme substrate 1	cyclin A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex
	Molecular Function	Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Nervous System Development Cell Division Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Cell Division
Pathways		Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Factors involved in megakaryocyte development and platelet production	G0 and Early G1 Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 23563607 25282103 25429064 20881960 20189936 28552196 31562340 18391951 28270201) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Hypertriglyceridemia ( 23505323) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494 27863252) Neurofibrillary tangles ( 31497858) Platelet count ( 27863252 29403010 32888494 24026423 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Scalp hair shape ( 26926045) Sitting height ratio ( 25865494) Smoking behavior ( 19247474) Tuberculosis ( 20694014) Waist circumference ( 31928498) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 28552196 28448500 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Cocaine dependence ( 31212010) Nickel levels ( 26025379)
Interacting Genes		8 interacting genes: ABL1 CCNA1 CCNE1 CDK3 CDK5 TDRD7 TP53 TP73	40 interacting genes: ANAPC4 ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 FZR1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 PSMA2 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC TRIM13 WEE1 XRCC6
Entrez ID		91768	8900
HPRD ID		16461	04946
Ensembl ID		ENSG00000134508	ENSG00000133101
Uniprot IDs		A7K6Y5 Q8TDN4	A0A140VJG0 P78396
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex P53 Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle MDM2/MDM4 Family Protein Binding Neuron Apoptotic Process Anatomical Structure Morphogenesis Organelle Organization Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Release Of Cytochrome C From Mitochondria Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Process Mismatch Repair Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Growth Negative Regulation Of Growth Kinase Activity T Cell Differentiation In Thymus Postsynaptic Density Negative Regulation Of Cell Differentiation Somitogenesis Regulation Of Cellular Senescence Cytoplasm Cerebellum Development Segmentation DNA Metabolic Process Regulation Of Cell Cycle Process Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Developmental Growth DNA Damage Response Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Senescence Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cyclin Binding Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleus Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Catalytic Activity Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Regulation Of Kinase Activity Regulation Of Metabolic Process Chromosome, Telomeric Region Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Phosphorylation Regulation Of Lipid Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Regulation Of Protein Modification Process Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Metabolic Process
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