CABLES1 and CDK3

Number of citations of the paper that reports this interaction (PubMedID 11733001)
0

Data Source:
HPRD (in vitro, in vivo)

		CABLES1	CDK3
Description		Cdk5 and Abl enzyme substrate 1	cyclin dependent kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Nervous System Development Cell Division Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Signal Transduction Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Cell Division
Pathways		Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 23563607 25282103 25429064 20881960 20189936 28552196 31562340 18391951 28270201) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Hypertriglyceridemia ( 23505323) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494 27863252) Neurofibrillary tangles ( 31497858) Platelet count ( 27863252 29403010 32888494 24026423 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Scalp hair shape ( 26926045) Sitting height ratio ( 25865494) Smoking behavior ( 19247474) Tuberculosis ( 20694014) Waist circumference ( 31928498) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 28552196 28448500 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: ABL1 CCNA1 CCNE1 CDK3 CDK5 TDRD7 TP53 TP73	38 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS2 E2F1 E2F2 E2F3 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63
Entrez ID		91768	1018
HPRD ID		16461	00446
Ensembl ID		ENSG00000134508	ENSG00000250506
Uniprot IDs		A7K6Y5 Q8TDN4	Q00526
PDB IDs			7XQK 8H4R
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex P53 Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle MDM2/MDM4 Family Protein Binding Neuron Apoptotic Process Anatomical Structure Morphogenesis Organelle Organization Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Release Of Cytochrome C From Mitochondria Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Process Mismatch Repair Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Growth Negative Regulation Of Growth Kinase Activity T Cell Differentiation In Thymus Postsynaptic Density Negative Regulation Of Cell Differentiation Somitogenesis Regulation Of Cellular Senescence Cytoplasm Cerebellum Development Segmentation DNA Metabolic Process Regulation Of Cell Cycle Process Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Developmental Growth DNA Damage Response Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Senescence Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Binding Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Rb-E2F Complex Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Division Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Regulation Of Gene Expression Epithelial Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Tissue Regeneration Medial Motor Column Neuron Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition DNA Binding Positive Regulation Of Mitotic Cell Cycle Cyclin E1-CDK2 Complex Regulation Of Protein Kinase Activity
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