MYOM2 and NEB

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MYOM2	NEB
Description		myomesin 2	nebulin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion M Band Myosin Filament	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myofibril Sarcomere Z Disc Contractile Muscle Fiber Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Muscle Kinase Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding
	Biological Process	Extraocular Skeletal Muscle Development Muscle Contraction Sarcomere Organization	Muscle Organ Development Somatic Muscle Development Regulation Of Actin Filament Length Cardiac Muscle Thin Filament Assembly
Pathways			Striated Muscle Contraction
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Ankylosing spondylitis ( 30946743) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density x serum urate levels interaction ( 34046847) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Opioid use cessation ( 31936517) Toenail selenium levels ( 25343990)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Skeletal muscle index ( 33674626) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		14 interacting genes: ANKRD1 CKM DYSF HSPB2 JMJD1C MYBPC2 MYH7 MYH9 NEB RPS6 SEC31A TAF1 TNNT1 TTN	25 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN USP7 XIRP1 XIRP2
Entrez ID		9172	4703
HPRD ID		04619	01196
Ensembl ID		ENSG00000036448	ENSG00000183091
Uniprot IDs		P54296	P20929 Q05C45 Q96MF8
PDB IDs			1ARK 1NEB 6Y17
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Actomyosin Structure Organization Actin Filament-based Process Myosin Filament Somatic Muscle Development Actin-mediated Cell Contraction Skeletal Muscle Contraction Actin Cytoskeleton Organization Structural Constituent Of Muscle Myofibril Transition Between Fast And Slow Fiber Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Actin Filament Binding Muscle Tissue Morphogenesis Supramolecular Fiber Regulation Of Skeletal Muscle Adaptation Striated Muscle Contraction Muscle Filament Sliding Actin-myosin Filament Sliding Actin Binding M Band Cardiac Muscle Hypertrophy Z Disc Myosin II Complex Response To Muscle Stretch I Band Muscle Hypertrophy Microfilament Motor Activity Calmodulin Binding Muscle Contraction Cardiac Muscle Contraction Cytoskeleton Organization Myosin Complex Cytoskeletal Motor Activity Cortical Granule Exocytosis Positive Regulation Of Androgen Receptor Signaling Pathway Slow-twitch Skeletal Muscle Fiber Contraction Monocyte Activation Involved In Immune Response Sarcomere Muscle System Process Regulation Of The Force Of Skeletal Muscle Contraction Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Uropod Organization Actin Cytoskeleton Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Negative Regulation Of Protein Autoubiquitination P53 Binding Titin-telethonin Complex	Muscle Contraction Actin Binding Actin Cytoskeleton Organization Muscle System Process Actin Filament Organization Actin Filament-based Process Actomyosin Structure Organization Supramolecular Fiber Organization Z Disc Cytoskeletal Protein Binding Cytoplasm Striated Muscle Thin Filament Actin Filament Binding Sarcomere Organization Structural Constituent Of Muscle Cytoskeleton Organization Sarcomere M Band Stress Fiber Myofibril Assembly Muscle Thin Filament Tropomyosin System Process Cytoskeleton Anchoring Junction Pointed-end Actin Filament Capping Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Organelle Organization Actin Filament-based Movement Titin Binding Contractile Muscle Fiber Tropomyosin Binding Muscle Tissue Morphogenesis Cell Junction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Muscle Filament Sliding Muscle Alpha-actinin Binding Protein Kinase Regulator Activity Actin Filament Actin-myosin Filament Sliding Regulation Of Protein Depolymerization Skeletal Muscle Organ Development Protein Kinase Binding Myosin Filament Megakaryocyte Development Regulation Of Actin Filament Organization I Band Cytosol Regulation Of Protein-containing Complex Disassembly
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