MYOM2 and MYH9

Number of citations of the paper that reports this interaction (PMID 9529381)
15

Data Source:
HPRD (in vitro)

		MYOM2	MYH9
Gene Name		myomesin 2	myosin, heavy chain 9, non-muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion M Band Myosin Filament	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament
	Molecular Function	Protein Binding Structural Constituent Of Muscle	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding
	Biological Process	Muscle Contraction	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation
Pathways			EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS			End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		3 interactors: CKM MYH9 TTN	22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ
Entrez ID		9172	4627
HPRD ID		04619	01177
Ensembl ID		ENSG00000036448	ENSG00000100345
Uniprot IDs		P54296	P35579
PDB IDs			2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Actin Filament-based Movement Actomyosin Structure Organization Phosphocreatine Biosynthetic Process Platelet Activation Striated Muscle Cell Differentiation Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Muscle Cell Differentiation Myosin Filament Assembly Establishment Of T Cell Polarity Uropod Organization Establishment Of Meiotic Spindle Localization Skeletal Muscle Thin Filament Assembly Blood Coagulation Hemostasis Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Creatine Metabolic Process Muscle Structure Development In Utero Embryonic Development Meiotic Spindle Organization Regulation Of Body Fluid Levels Wound Healing Actin Cytoskeleton Organization Adult Heart Development Actin Filament-based Process Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Cell Activation Response To Wounding Myoblast Fusion Platelet Formation Cardiac Myofibril Assembly Platelet Morphogenesis Cardiac Muscle Hypertrophy Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Mitotic Chromosome Condensation Muscle Hypertrophy Cardiovascular System Development Muscle Filament Sliding Actin-myosin Filament Sliding Syncytium Formation Blood Vessel Endothelial Cell Migration Membrane Protein Proteolysis Platelet Aggregation Actin-mediated Cell Contraction	Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development
Tagcloud ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 herpud1 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Difference) ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 herpud1 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Intersection) ?