IKZF2 and IKZF5

Number of citations of the paper that reports this interaction (PubMedID 10978333)
0

Data Source:
HPRD (in vitro)

		IKZF2	IKZF5
Description		IKAROS family zinc finger 2	IKAROS family zinc finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Eosinophil count ( 19198610 32888494 27863252 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31451708) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Selective IgA deficiency ( 27723758) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systemic sclerosis ( 29293537) Type 2 diabetes ( 32499647)
Interacting Genes		10 interacting genes: AQP1 CFTR CTBP1 CTBP2 HDAC4 IKZF1 IKZF4 IKZF5 LONRF1 TCEANC	9 interacting genes: CCDC85B IKZF1 IKZF2 IKZF3 IKZF4 LDOC1 NUDT22 PIAS1 UBE2I
Entrez ID		22807	64376
HPRD ID		05872	05873
Ensembl ID		ENSG00000030419	ENSG00000095574
Uniprot IDs		B4DWF2 Q9UKS7	Q9H5V7
PDB IDs		7LPS 8DEY
Enriched GO Terms of Interacting Partners?		Transepithelial Water Transport Protein Domain Specific Binding Transcription Repressor Complex Epithelial Fluid Transport Negative Regulation Of DNA-templated Transcription White Fat Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Viral Genome Replication Negative Regulation Of RNA Metabolic Process Water Transport Multicellular Organismal-level Water Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Fluid Transport Transepithelial Transport NAD Binding Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Cellular Response To CAMP Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Corepressor Binding Multicellular Organismal-level Chemical Homeostasis Protein-containing Complex Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Positive Regulation Of Anion Channel Activity Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To CAMP Positive Regulation Of Saliva Secretion Odontogenesis Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Monoatomic Anion Transport Axonemal Central Apparatus Regulation Of RNA Metabolic Process Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol SUMO Transferase Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Protein Domain Specific Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Protein Sumoylation Mesoderm Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II SUMO Conjugating Enzyme Activity GDP-mannose Hydrolase Activity Nucleoplasm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding UDP-sugar Diphosphatase Activity PML Body RING-like Zinc Finger Domain Binding Zinc Ion Binding SUMO Ligase Complex HLH Domain Binding Nucleus DNA Binding Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Small Protein Activating Enzyme Binding Maternal Process Involved In Parturition Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Metal Ion Binding Delta-catenin Binding Mitotic Nuclear Membrane Reassembly Maternal Placenta Development Cellular Response To Muramyl Dipeptide Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transferase Complex SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Lymphocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?