SUN2 and SRSF10

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SUN2	SRSF10
Description		Sad1 and UNC84 domain containing 2	serine and arginine rich splicing factor 10
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Nuclear Envelope Nuclear Inner Membrane Endosome Endosome Membrane Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Dendrite Neuronal Cell Body Axon Terminus
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RS Domain Binding Unfolded Protein Binding
	Biological Process	Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription MRNA Splice Site Recognition MRNA Processing RNA Splicing Cytosolic Transport Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Meiotic synapsis	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Chronotype ( 30696823) Obesity-related traits ( 23251661)
Interacting Genes		6 interacting genes: HGS NRM PRPF6 RAB5B RPS20 SRSF10	24 interacting genes: CLK1 CLK2 CLK3 CLK4 CSNK2A1 DAPK1 DYRK1A EXOSC8 FBXO7 FUS H19 MPP1 PTPN11 SNRNP70 SREK1 SRPK1 SRSF1 SRSF4 SUN2 SYCE1L TRA2A TRA2B YWHAB YWHAG
Entrez ID		25777	10772
HPRD ID		15611	05562
Ensembl ID		ENSG00000100242	ENSG00000188529
Uniprot IDs		B0QY60 B0QY64 B4E2A6 Q9UH99	A0A0S2Z504 B3KNY6 O75494 Q5JRI1
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9 6WMD 6WME 6WMF 6WMG
Enriched GO Terms of Interacting Partners?		Endosome Organization Spliceosomal Tri-snRNP Complex Assembly	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Protein Serine/threonine/tyrosine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity MRNA Metabolic Process Nuclear Speck Protein Kinase Activity Nucleus Protein Tyrosine Kinase Activity Kinase Activity RNA Processing Regulation Of Gene Expression MRNA Processing RNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Identical Protein Binding Nucleic Acid Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphorylation Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein Targeting Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Binding ATP Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Autophosphorylation Negative Regulation Of RNA Splicing Negative Regulation Of Gene Expression Regulation Of Response To Tumor Cell Positive Regulation Of Metabolic Process
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