CNOT9 and GADD45G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNOT9	GADD45G
Description		CCR4-NOT transcription complex subunit 9	growth arrest and DNA damage inducible gamma
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex	Nucleus Cytoplasm
	Molecular Function	Transcription Coactivator Activity Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Regulation Of Translation Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade
Pathways		Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 26561523 28107422) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32154731 32203549)
Interacting Genes		11 interacting genes: AKT1 EGFR GADD45A GADD45B GADD45G GIGYF1 GIGYF2 GRB10 MESD MYB OBI1	74 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDK11A CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLAGL2 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763
Entrez ID		9125	10912
HPRD ID		08828	05383
Ensembl ID		ENSG00000144580	ENSG00000130222
Uniprot IDs		D5MQE1 Q92600	O95257
PDB IDs		2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON 9FL8	2WAL 3FFM
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of P38MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Enzyme-linked Receptor Protein Signaling Pathway Response To UV-A Kinase Binding Positive Regulation Of JNK Cascade Protein-containing Complex Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Apoptotic Process Regulation Of JNK Cascade Regulation Of G1/S Transition Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Programmed Cell Death Regulation Of Glycogen Biosynthetic Process Regulation Of Protein Localization To Membrane Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Apoptotic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Epidermal Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Fibroblast Proliferation Positive Regulation Of MiRNA Transcription Regulation Of TRNA Methylation Regulation Of D-glucose Import Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Multivesicular Body, Internal Vesicle Lumen Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Epidermal Growth Factor Receptor Signaling Pathway	Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Regulation Of MiRNA Transcription Protein Binding Regulation Of MiRNA Metabolic Process Nuclear Steroid Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin B1-CDK1 Complex PCNA-p21 Complex Peroxisome Proliferator Activated Receptor Signaling Pathway Microtubule Cytoskeleton Organization Involved In Mitosis RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Gene Expression Sequence-specific DNA Binding Cyclin-dependent Protein Kinase Holoenzyme Complex Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Transcription Coactivator Binding Regulation Of Cell Population Proliferation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport DNA Binding Domain Binding Negative Regulation Of Lipid Storage Regulation Of Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centrosome Rhythmic Process Response To Estradiol Retinoic Acid Receptor Signaling Pathway Regulation Of Circadian Rhythm Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Molecular Function Activator Activity Positive Regulation Of Lipoprotein Transport Establishment Of Organelle Localization Organelle Localization Chromatin Negative Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regeneration Positive Regulation Of Chromosome Segregation
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