USP14 and ISG15

Number of citations of the paper that reports this interaction (PubMedID 35962463)
0

Data Source:
BioGRID (pull down)

		USP14	ISG15
Description		ubiquitin specific peptidase 14	ISG15 ubiquitin like modifier
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GO Annotations	Cellular Component	Proteasome Complex Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Synapse Extracellular Exosome Glutamatergic Synapse Presynaptic Cytosol	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Proteasome Binding Deubiquitinase Activity	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Immune System Process Proteolysis Inflammatory Response Chemical Synaptic Transmission Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion
Pathways		Ub-specific processing proteases Regulation of NF-kappa B signaling	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Blood protein levels ( 30072576)
Interacting Genes		19 interacting genes: ATF2 CDK1 CEBPA CXCR4 FANCC ISG15 OGT PSMD2 SEM1 SGTA SPAG5-AS1 TAFAZZIN TGFBR1 TRIM11 UBC USP15 USP21 USP28 XRCC6	25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5
Entrez ID		9097	9636
HPRD ID		06279	00958
Ensembl ID		ENSG00000101557	ENSG00000187608
Uniprot IDs		P54578	P05161
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M	1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Protein Modification Process Response To Stress Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Post-translational Protein Modification Nucleus Regulation Of Multicellular Organismal Development Protein-containing Complex Protein Tag Activity Cysteine-type Deubiquitinase Activity Cellular Response To Stress DNA Damage Response White Fat Cell Differentiation DNA Damage Checkpoint Signaling Cellular Response To Chemical Stress DNA Repair Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Deubiquitinase Activity Cysteine-type Peptidase Activity Regulation Of Developmental Process Negative Regulation Of Cell Cycle Cyclin Binding Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Response To Virus DNA Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Cell Population Proliferation Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding
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