USP14 and XRCC6

Number of citations of the paper that reports this interaction (PubMedID 31740976)
53

Data Source:
BioGRID (enzymatic study)

		USP14	XRCC6
Description		ubiquitin specific peptidase 14	X-ray repair cross complementing 6
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Synapse Extracellular Exosome Glutamatergic Synapse Presynaptic Cytosol	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Proteasome Binding Deubiquitinase Activity	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Lyase Activity ATP Hydrolysis Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity Scaffold Protein Binding
	Biological Process	Immune System Process Proteolysis Inflammatory Response Chemical Synaptic Transmission Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Ub-specific processing proteases Regulation of NF-kappa B signaling	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Asthma ( 34103634) Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ATF2 CDK1 CEBPA CXCR4 FANCC ISG15 OGT PSMD2 SEM1 SGTA SPAG5-AS1 TAFAZZIN TGFBR1 TRIM11 UBC USP15 USP21 USP28 XRCC6	144 interacting genes: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCNB1 CCT3 CD40 CDCA5 CDK1 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DEAF1 DLX2 DNTT DSCR4 DUX4 DYRK1A DYSF EFNA1 EGFR EID1 EIF4ENIF1 ELF3 EP300 EPS8 ETS1 FCER2 FILNC1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HACL2 HERPUD1 HOXB7 HOXC4 HOXD4 HSF1 HTT JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 OGT PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF10 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERT TP53 UBC USP14 VAV1 VBP1 WBP4 WEE2-AS1 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		9097	2547
HPRD ID		06279	01071
Ensembl ID		ENSG00000101557	ENSG00000196419
Uniprot IDs		P54578	B1AHC9 B4DE32 B4E356 P12956
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M	1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE 7AXZ 7K0Y 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4
Enriched GO Terms of Interacting Partners?		Nucleoplasm Macromolecule Metabolic Process Protein Metabolic Process Protein Modification Process Response To Stress Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Post-translational Protein Modification Nucleus Regulation Of Multicellular Organismal Development Protein-containing Complex Protein Tag Activity Cysteine-type Deubiquitinase Activity Cellular Response To Stress DNA Damage Response White Fat Cell Differentiation DNA Damage Checkpoint Signaling Cellular Response To Chemical Stress DNA Repair Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Peptidyl-threonine Phosphorylation Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Deubiquitinase Activity Cysteine-type Peptidase Activity Regulation Of Developmental Process Negative Regulation Of Cell Cycle Cyclin Binding Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Response To Virus DNA Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Pronuclear Fusion Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Cell Population Proliferation Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Abducens Nucleus Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Response To Stress DNA Metabolic Process DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Protein-containing Complex Regulation Of Protein Stability Chromatin Negative Regulation Of Programmed Cell Death Double-strand Break Repair Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II
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