OTULIN and DAZAP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OTULIN	DAZAP2
Gene Name		OTU deubiquitinase with linear linkage specificity	DAZ associated protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm LUBAC Complex	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding WW Domain Binding
	Biological Process	Sprouting Angiogenesis Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DAZAP2 DVL2 FAM168A UBC VCP	86 interactors: AATF ARID5A ATXN1 ATXN1L BAG3 BATF2 C1orf94 CALCOCO2 CCDC120 CDK4 CEP70 CLASRP COL4A2 COL4A5 CXCL12 DAB1 DAZ1 DAZL DCUN1D1 EPN1 EXD3 FAM168A FAM46B FAM46C FBN3 GPSM1 HGS HIP1 KRTAP19-5 KRTAP8-1 LASP1 LMO2 MED31 NDUFA5 NEDD4 NEDD4L NOC4L OPTN OTULIN PEF1 PLEKHB2 PLSCR1 POGZ POLI PRR20A RABGEF1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF115 RNF208 ROR2 RPS27A SEPT2 SMAP2 SMURF2 SOX6 SQSTM1 STAM2 STAT6 TAX1BP1 TCF7L2 TEX37 TLE1 TNIP3 TOLLIP UBA52 UBAC1 UBASH3A UBASH3B UBB UBC UBE2D4 UBE2E2 UBQLN4 USP5 VHLL VPS37C WDR73 WWP1 ZC3H10 ZFAND2B ZFYVE9 ZNF34 ZNF581
Entrez ID		90268	9802
HPRD ID		14266	08463
Ensembl ID		ENSG00000154124	ENSG00000183283
Uniprot IDs		Q96BN8	E9PB45 Q15038
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Convergent Extension Involved In Neural Plate Elongation Proteasomal Protein Catabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retrograde Protein Transport, ER To Cytosol Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Deubiquitination Convergent Extension Involved In Organogenesis Regulation Of Protein Catabolic Process Protein Hexamerization Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of Protein Kinase Activity Aggresome Assembly Positive Regulation Of Kinase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Translesion Synthesis Viral Protein Processing Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure	Negative Regulation Of Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Viral Protein Processing Regulation Of ERBB Signaling Pathway Protein Ubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Signaling Intracellular Transport Of Virus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process RNA Biosynthetic Process Endosomal Transport Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Transforming Growth Factor Beta Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
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