OTULIN and OTUD7B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTULIN	OTUD7B
Description		OTU deubiquitinase with linear linkage specificity	OTU deubiquitinase 7B
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	DNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding K48-linked Deubiquitinase Activity
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Immune System Process Mucosal Immune Response Proteolysis Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination TORC1 Signaling TORC2 Signaling Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851 34103634) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058) DHEAS levels ( 34748635)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: BCL10 CRYAA DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBC	19 interacting genes: ATG14 CCNB1 CDC20 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 OTULIN PIK3C3 PSMB1 SAXO4 SOX2 SPART TRAF6 UBC UBE2S ZDHHC17
Entrez ID		90268	56957
HPRD ID		14266	10313
Ensembl ID		ENSG00000154124	ENSG00000264522
Uniprot IDs		Q96BN8	Q6GQQ9
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	5LRU 5LRV 5LRW
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein K63-linked Deubiquitination	Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Cell Division Positive Regulation Of Post-translational Protein Modification Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Phosphatidylinositol 3-kinase Complex, Class III Ubiquitin-protein Transferase Activator Activity Proteolysis Regulation Of Protein Ubiquitination Ubiquitin Ligase Activator Activity Protein Ubiquitination Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Post-translational Protein Modification Autophagosome Assembly Cytoplasm Autophagosome Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Targeting To Lysosome Positive Regulation Of Catalytic Activity Phagophore Assembly Site Modification-dependent Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Response To DDT Cell Cycle Phase Transition Metaphase/anaphase Transition Of Meiosis I Macroautophagy Extrinsic Component Of Phagophore Assembly Site Membrane Negative Regulation Of Collateral Sprouting In Absence Of Injury Perforant Pathway To Dendrate Granule Cell Synapse Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Vacuole Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Glucose Starvation Autophagosome Maturation
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