OTULIN

Gene Name		OTU deubiquitinase with linear linkage specificity
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Gene Ontology Annotations	Cellular Component	Cytoplasm LUBAC Complex
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Sprouting Angiogenesis Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: DAZAP2 DVL2 FAM168A UBC VCP
Entrez ID		90268
HPRD ID		14266
Ensembl ID		ENSG00000154124
Uniprot IDs		Q96BN8
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Convergent Extension Involved In Neural Plate Elongation Proteasomal Protein Catabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retrograde Protein Transport, ER To Cytosol Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Deubiquitination Convergent Extension Involved In Organogenesis Regulation Of Protein Catabolic Process Protein Hexamerization Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of Protein Kinase Activity Aggresome Assembly Positive Regulation Of Kinase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Translesion Synthesis Viral Protein Processing Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure
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