OTULIN

Description		OTU deubiquitinase with linear linkage specificity
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851 34103634) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058) DHEAS levels ( 34748635)
Interacting Genes		12 interacting genes: BCL10 CRYAA DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBC
Entrez ID		90268
HPRD ID		14266
Ensembl ID		ENSG00000154124
Uniprot IDs		Q96BN8
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein K63-linked Deubiquitination
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