OTULIN and SPATA2

Number of citations of the paper that reports this interaction (PubMedID 27545878)
42

Data Source:
BioGRID (unspecified method)

		OTULIN	SPATA2
Description		OTU deubiquitinase with linear linkage specificity	spermatogenesis associated 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Protein K63-linked Deubiquitination Seminiferous Tubule Development Protein Linear Deubiquitination
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851 34103634) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058) DHEAS levels ( 34748635)	Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 18364390 20953189 25574825)
Interacting Genes		12 interacting genes: BCL10 CRYAA DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBC	22 interacting genes: ANKRD11 APP ATP6V1H CATSPERT CCDC102B CEP72 DUT EFHC1 GOLGA2 GPANK1 KAT5 KIFC3 LENG1 MAD1L1 OTULIN PTPN6 TBC1D22B TNIP1 TRAF2 TRIM27 UBC ZNF835
Entrez ID		90268	9825
HPRD ID		14266	09636
Ensembl ID		ENSG00000154124	ENSG00000158480
Uniprot IDs		Q96BN8	A8K0S9 B4DID4 Q9UM82
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	5LJM 5LJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein K63-linked Deubiquitination	Microtubule-based Process Spindle Pole Pattern Recognition Receptor Signaling Pathway CD27 Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Segregation Innate Immune Response-activating Signaling Pathway Innate Immune Response Activation Of Innate Immune Response Regulation Of Metaphase Plate Congression Identical Protein Binding Regulation Of Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Serine/threonine Kinase Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus DUTP Catabolic Process DUTP Diphosphatase Activity Spindle Organization Positive Regulation Of Protein Modification Process Mitotic Spindle Regulation Of Autophagy Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Innate Immune Response Epididymis Development Immune Response-activating Signaling Pathway TORC2 Complex Disassembly Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Chromosome Segregation MAD1 Complex Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Microtubule-based Movement Regulation Of Cytokine-mediated Signaling Pathway Cytoskeleton Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response
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