OTULIN and SPART

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTULIN	SPART
Description		OTU deubiquitinase with linear linkage specificity	spartin
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding Lipid Binding Ubiquitin Protein Ligase Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Lipid Metabolic Process Lipid Transport Lipid Catabolic Process BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Collateral Sprouting In Absence Of Injury Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development Lipophagy Midbody Abscission Regulation Of Biological Quality
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Asthma ( 31619474 31959851 34103634) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058) DHEAS levels ( 34748635)
Interacting Genes		12 interacting genes: BCL10 CRYAA DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBC	21 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		90268	23111
HPRD ID		14266	06170
Ensembl ID		ENSG00000154124	ENSG00000133104
Uniprot IDs		Q96BN8	A0A024RDV9 Q8N0X7
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	2DL1 4U7I
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein K63-linked Deubiquitination	Cysteine-type Deubiquitinase Activity Protein K48-linked Deubiquitination Early Endosome Membrane Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Cytosol K48-linked Deubiquitinase Activity Endosome Early Endosome Deubiquitinase Activity Protein K63-linked Deubiquitination Proteolysis Protein Modification Process Cytoplasm Endocytosis Peptidase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization Import Into Cell Protein Ubiquitination Response To Mechanical Stimulus Negative Regulation Of Leukocyte Activation Regulation Of Immune Response Neuromuscular Junction Negative Regulation Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cell Activation Protein Modification By Small Protein Conjugation K63-linked Deubiquitinase Activity Regulation Of Notch Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ubiquitin Binding Regulation Of Signaling Ubiquitin Ligase Complex Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Vesicle-mediated Transport Symbiont Entry Into Host Cell Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Transporter Activity Regulation Of Signal Transduction
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