UBE2V1 and KITLG

Number of citations of the paper that reports this interaction (PubMedID 12481031)
29

Data Source:
HPRD (in vitro)

		UBE2V1	KITLG
Description		ubiquitin conjugating enzyme E2 V1	KIT ligand
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Filopodium Cell Projection
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Conjugating Enzyme Activity	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of DNA-templated Transcription Cell Differentiation Error-free Postreplication DNA Repair Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction	Ovarian Follicle Development Neural Crest Cell Migration Hematopoietic Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Developmental Process Involved In Reproduction Apoptotic Process Cell Adhesion Ras Protein Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Melanocyte Migration Mast Cell Migration Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Familial progressive hyperpigmentation
GWAS			Aspartate aminotransferase levels ( 33547301) Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Facial skin colour (CIELAB index b* value) ( 34648798) Facial skin colour (CIELAB index L* value) ( 34648798) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240 23666239 19483681) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		49 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM21 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBE3B UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1 ZNRF2	9 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD S100A6 UBE2V1
Entrez ID		7335	4254
HPRD ID		04294	01698
Ensembl ID		ENSG00000244687	ENSG00000049130
Uniprot IDs		G3V2F7 Q13404	P21583
PDB IDs		2A4D 2C2V 2HLW 6D6I	1EXZ 1SCF 2E9W 8DFM 8DFP 8DFQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Metal Ion Binding Regulation Of Innate Immune Response ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Suppression Of Viral Release By Host Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Immune Response	Positive Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mast Cell Migration Erythropoietin-mediated Signaling Pathway Mononuclear Cell Differentiation Leukocyte Differentiation B Cell Differentiation Regulation Of Cell Population Proliferation Myeloid Leukocyte Differentiation Embryonic Hemopoiesis Embryonic Organ Development Positive Regulation Of Leukocyte Proliferation Mast Cell Degranulation B Cell Activation Leukocyte Activation Dendritic Cell Differentiation Leukocyte Degranulation Extracellular Region Cell Activation Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Leukocyte Proliferation Developmental Process Extracellular Space Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Erythropoietin Receptor Activity Lysosome Localization Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway Error-free Postreplication DNA Repair Basement Membrane Disassembly Signal Transduction Lymphocyte Activation Regulated Exocytosis Cytoplasmic Side Of Plasma Membrane Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Natural Killer Cell Chemotaxis UBC13-MMS2 Complex Positive Regulation Of Cytokine Production Secretion Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide
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