UBE2V1 and TRAF3IP2

Number of citations of the paper that reports this interaction (PubMedID 19825828)
33

Data Source:
BioGRID (pull down)

		UBE2V1	TRAF3IP2
Description		ubiquitin conjugating enzyme E2 V1	TRAF3 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Conjugating Enzyme Activity	Signaling Receptor Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of DNA-templated Transcription Cell Differentiation Error-free Postreplication DNA Repair Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction	Protein Polyubiquitination Establishment Of T Cell Polarity B Cell Homeostasis B Cell Apoptotic Process Kidney Development Positive Regulation Of Defense Response To Virus By Host Leukocyte Activation Involved In Inflammatory Response Transitional Two Stage B Cell Differentiation B Cell Affinity Maturation Eosinophil Mediated Immunity Protein Import Into Nucleus Inflammatory Response Immune Response Humoral Immune Response Heart Development Response To Xenobiotic Stimulus Gene Expression Protein Ubiquitination Cytokine-mediated Signaling Pathway B Cell Mediated Immunity Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway T Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Protein Localization To Nucleus Intracellular Signal Transduction Interleukin-17A-mediated Signaling Pathway Type 2 Immune Response T Cell Activation Neutrophil Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Skin Development MRNA Stabilization Lymph Node Development Spleen Development Mucus Secretion Protein K63-linked Ubiquitination Cellular Response To Cytokine Stimulus T-helper 17 Type Immune Response Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Protein Localization To P-body Negative Regulation Of Interleukin-17-mediated Signaling Pathway Eosinophil Homeostasis
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Psoriasis ( 20953188 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 20953186 26626624) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		49 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM21 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBE3B UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1 ZNRF2	23 interacting genes: CD40 CHUK FHL3 GOLGA2 HSD17B10 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 TRIP6 UBC UBE2V1
Entrez ID		7335	10758
HPRD ID		04294	06129
Ensembl ID		ENSG00000244687	ENSG00000056972
Uniprot IDs		G3V2F7 Q13404	O43734
PDB IDs		2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Metal Ion Binding Regulation Of Innate Immune Response ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Suppression Of Viral Release By Host Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Immune Response	CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor Receptor Binding Thioesterase Binding TRIF-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Signal Transduction Involved In Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytoplasmic Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Other Organism Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Innate Immune Response IkappaB Kinase Complex Positive Regulation Of Immune Response Immune Response Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Defense Response To Symbiont Interleukin-17-mediated Signaling Pathway Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Transferrin Receptor Binding Defense Response Positive Regulation Of JUN Kinase Activity Toll-like Receptor Signaling Pathway Response To Virus Regulation Of Signal Transduction Identical Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?