UBE2V1 and ZNRF1

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2V1	ZNRF1
Gene Name		ubiquitin-conjugating enzyme E2 variant 1	zinc and ring finger 1, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome	Lysosome Endosome Cytosol Membrane Cell Junction Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Error-free Postreplication DNA Repair Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Innate Immune System TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		36 interactors: ARIH2 BIRC2 BIRC3 BIRC8 CHFR DTX3 DZIP3 FAM168A KITLG MID1 MKRN3 PARK2 PELI1 PELI3 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 RNF8 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 XIAP ZNRF1	13 interactors: CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W
Entrez ID		7335	84937
HPRD ID		04294	15893
Ensembl ID		ENSG00000244687	ENSG00000186187
Uniprot IDs		Q13404	Q8ND25
PDB IDs		2A4D 2C2V 2HLW
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction Cellular Macromolecule Catabolic Process Cellular Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stress	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Ubiquitin-protein Transferase Activity Postreplication Repair Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Cellular Response To Oxygen Levels Nucleotide-binding Oligomerization Domain Containing Signaling Pathway DNA Repair DNA Metabolic Process Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?		activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored
Tagcloud (Difference) ?		activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored
Tagcloud (Intersection) ?