TSR2 and EXOSC3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSR2	EXOSC3
Name		TSR2 ribosome maturation factor	exosome component 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Gene Expression Regulation Of Gene Expression U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		None	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
GWAS		Prostate cancer ( 31562322 )	No GWAS studies recorded
Interacting Genes		24 interacting genes: CAMK2A CMIP CREB5 DAPL1 DISC1 EXOSC3 GABARAP GABARAPL2 GAS2L3 GSC2 KIF16B KIFC3 LAMB2 MAP1LC3C MEOX2 PIAS2 PRKAB2 PTRHD1 RBM48 RPS26 SPATC1L ZBTB9 ZNF474 ZNF620	9 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 TSR2
Entrez ID		90121	51010
HPRD ID		06493	16220
Ensembl ID		ENSG00000158526	ENSG00000107371
Uniprot IDs		Q969E8	Q9NQT5
PDB IDs		Not available	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Microtubule Microtubule Binding Kinesin Complex Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome GABA Receptor Binding Autophagosome Assembly Cellular Response To Nutrient Levels Autophagosome Organization Phospholipid Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly	Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Exoribonuclease Complex U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process RRNA Processing RNA Processing RRNA Metabolic Process SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process DNA Deamination Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process Sno(s)RNA Metabolic Process MRNA Catabolic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA DNA Modification RNA Binding Nucleolus Response To Copper Ion RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Response To Other Organism MRNA Metabolic Process Negative Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Sebum Secreting Cell Proliferation Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Euchromatin Regulation Of Nitric Oxide Biosynthetic Process