TSR2 and LAMB2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSR2	LAMB2
Name		TSR2 ribosome maturation factor	laminin subunit beta 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Basement Membrane Laminin-3 Complex Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin Complex Laminin-11 Complex Synapse Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Protein Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Structural Constituent Of Synapse-associated Extracellular Matrix
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing	Cell Morphogenesis Cell Adhesion Axon Guidance Neuromuscular Junction Development Visual Perception Astrocyte Development Schwann Cell Development Neuron Projection Development Positive Regulation Of Cell Adhesion Axon Extension Involved In Regeneration Synapse Organization Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Metanephric Podocyte Development Metanephric Glomerular Basement Membrane Development Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		None	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Diseases		None	Pierson syndrome
GWAS		Prostate cancer ( 31562322 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Mood instability ( 31168069 ) Myocardial infarction ( 33532862 ) PR interval ( 32439900 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		24 interacting genes: CAMK2A CMIP CREB5 DAPL1 DISC1 EXOSC3 GABARAP GABARAPL2 GAS2L3 GSC2 KIF16B KIFC3 LAMB2 MAP1LC3C MEOX2 PIAS2 PRKAB2 PTRHD1 RBM48 RPS26 SPATC1L ZBTB9 ZNF474 ZNF620	12 interacting genes: ATXN7 CIP2A HOXA1 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 STIP1 TSR2 ZNF512B
Entrez ID		90121	3913
HPRD ID		06493	01034
Ensembl ID		ENSG00000158526	ENSG00000172037
Uniprot IDs		Q969E8	P55268
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Microtubule Microtubule Binding Kinesin Complex Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome GABA Receptor Binding Autophagosome Assembly Cellular Response To Nutrient Levels Autophagosome Organization Phospholipid Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly	None