TSR2 and KIF16B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSR2	KIF16B
Name		TSR2 ribosome maturation factor	kinesin family member 16B
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Endosome Early Endosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Lipid Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing	Formation Of Primary Germ Layer Regulation Of Receptor Recycling Golgi To Endosome Transport Microtubule-based Movement Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Endoderm Development Fibroblast Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Receptor Catabolic Process Early Endosome To Late Endosome Transport Vesicle Transport Along Microtubule
Pathways		None	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
GWAS		Prostate cancer ( 31562322 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Asthma ( 27611488 ) Body mass index ( 26426971 ) Chronotype ( 30696823 ) Dimensional psychopathology (Positive) ( 29496196 ) Emphysema imaging phenotypes ( 26030696 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Gut microbiota alpha diversity (Shannon index) ( 33208821 ) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821 ) HDL cholesterol levels in HIV infection ( 33109212 ) Hodgkin's lymphoma ( 34216518 ) Ileal carcinoids ( 21139019 ) Intelligence ( 22449649 ) LDL cholesterol levels in HIV infection ( 33109212 ) Lipid traits ( 30576415 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Sweet taste preference ( 32572145 )
Interacting Genes		24 interacting genes: CAMK2A CMIP CREB5 DAPL1 DISC1 EXOSC3 GABARAP GABARAPL2 GAS2L3 GSC2 KIF16B KIFC3 LAMB2 MAP1LC3C MEOX2 PIAS2 PRKAB2 PTRHD1 RBM48 RPS26 SPATC1L ZBTB9 ZNF474 ZNF620	10 interacting genes: GABARAPL2 GINS4 IL16 ITSN1 LGALS3 PRKAA1 PRKAA2 SMYD1 TCEANC TSR2
Entrez ID		90121	55614
HPRD ID		06493	10731
Ensembl ID		ENSG00000158526	ENSG00000089177
Uniprot IDs		Q969E8	A0A140VK74 A0A1B0GTU3 A0A1B0GVS8 Q96L93
PDB IDs		Not available	2V14 6EE0
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Microtubule Microtubule Binding Kinesin Complex Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome GABA Receptor Binding Autophagosome Assembly Cellular Response To Nutrient Levels Autophagosome Organization Phospholipid Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly	Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Lipid Droplet Negative Regulation Of Tubulin Deacetylation Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Cellular Response To Prostaglandin E Stimulus Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein K6-linked Ubiquitination Response To Prostaglandin E Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Cellular Response To Starvation Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process Lipid Droplet Organization Response To Starvation Sterol Biosynthetic Process Regulation Of Release Of Cytochrome C From Mitochondria Epithelial Cell Apoptotic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Glucose Starvation Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Regulation Of Epithelial Cell Apoptotic Process Protein Localization To Lysosome Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Cellular Response To Xenobiotic Stimulus Autophagy Negative Regulation Of Glucosylceramide Biosynthetic Process Cellular Response To Glucose Stimulus Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Phosphatidylcholine Metabolic Process TORC1 Signaling Energy Homeostasis