KBTBD7 and CPT1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KBTBD7	CPT1A
Gene Name		kelch repeat and BTB (POZ) domain containing 7	carnitine palmitoyltransferase 1A (liver)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Molecular_function Protein Binding	Carnitine O-palmitoyltransferase Activity Identical Protein Binding
	Biological Process	Biological_process	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Response To Organic Cyclic Compound Epithelial Cell Differentiation Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Fatty Acid
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) RORA activates circadian gene expression
Drugs			L-Carnitine Perhexiline
Diseases
GWAS			Lipid metabolism phenotypes ( 22286219) Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BARD1 BLMH C8orf33 CPT1A DUSP23 GABARAPL1 GABARAPL2 HAP1 LINC00341 LRIF1 MAP1LC3B NFKBIE PHC2	7 interactors: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1
Entrez ID		84078	1374
HPRD ID		13759	02755
Ensembl ID			ENSG00000110090
Uniprot IDs		Q8WVZ9	B2RAQ8 P50416 Q8WZ48
PDB IDs			2LE3
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Autophagy Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Nitrogen Starvation Cellular Response To Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Cellular Response To Stress Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Mitochondrion Organization Catabolic Process Negative Regulation Of Intracellular Protein Transport Response To Nutrient Levels Regulation Of Cellular Localization Regulation Of Intracellular Transport D-serine Transport Negative Regulation Of MRNA 3'-end Processing Response To Extracellular Stimulus Organelle Assembly Negative Regulation Of Intracellular Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Response To Drug Regulation Of Protein Transport Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Polyubiquitination Negative Regulation Of Protein Export From Nucleus Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Transport Protein K6-linked Ubiquitination Positive Regulation Of Fatty Acid Beta-oxidation Carnitine Shuttle Regulation Of Nucleocytoplasmic Transport Hypothalamus Cell Differentiation Negative Regulation Of Beta-amyloid Formation Regulation Of Protein Localization Retrograde Axon Cargo Transport Carnitine Transmembrane Transport Carnitine Transport Membrane Organization Regulation Of Intracellular Protein Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process	Cellular Response To Glucose Starvation Regulation Of Mitochondrial Membrane Potential Response To Gamma Radiation Neural Nucleus Development Positive Regulation Of Endothelial Cell Proliferation Response To Nutrient Levels Response To Extracellular Stimulus Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Endothelial Cell Proliferation Renal System Process Negative Regulation Of Cellular PH Reduction Smooth Muscle Hypertrophy CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Body Fluid Levels Reactive Oxygen Species Metabolic Process Regulation Of Ion Transport Response To Stress Positive Regulation Of Cell Growth Metencephalon Development Cell Activation Response To External Stimulus Response To Wounding Cerebellum Structural Organization Response To Cytokine Cellular Response To Starvation Cellular Response To Organic Substance Response To Ionizing Radiation Positive Regulation Of Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Regulation Of Ion Homeostasis Innate Immune Response Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Regulation Of Renal Output By Angiotensin Positive Regulation Of Cell Proliferation Hindbrain Development Response To Toxic Substance Cellular Response To Nutrient Levels Response To Starvation Response To Organic Cyclic Compound Cochlear Nucleus Development Regulation Of Nitrogen Utilization Regulation Of Calcium Ion Transport Platelet Activation Intracellular Receptor Signaling Pathway Regulation Of Ossification Negative Regulation Of Apoptotic Process
Tagcloud ?			adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Difference) ?			adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Intersection) ?