PPID and HSPA8

Number of citations of the paper that reports this interaction (PMID 15497503)
9

Data Source:
HPRD (in vitro)

		PPID	HSPA8
Gene Name		peptidylprolyl isomerase D	heat shock 70kDa protein 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Ubiquitin Ligase Complex Prp19 Complex Extracellular Space Intracellular Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytosol Plasma Membrane Focal Adhesion Membrane Ribonucleoprotein Complex Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Cyclosporin A Binding Estrogen Receptor Binding Hsp70 Protein Binding Heat Shock Protein Binding Hsp90 Protein Binding	G-protein Coupled Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Peptidyl-prolyl Isomerization Protein Folding Protein Complex Assembly Apoptotic Process Protein Transport Viral Release From Host Cell Lipid Particle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Chaperone-mediated Protein Folding Cellular Response To UV-A	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Protein Folding Post-Golgi Vesicle-mediated Transport Response To Unfolded Protein Synaptic Transmission Neurotransmitter Secretion Axon Guidance RNA Splicing Gene Expression Viral Process Cellular Response To Heat Protein Refolding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Cell Cycle Membrane Organization Clathrin Coat Disassembly Regulation Of Cellular Response To Heat Negative Regulation Of Fibril Organization
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Regulation of mRNA stability by proteins that bind AU-rich elements Axon guidance Golgi Associated Vesicle Biogenesis Attenuation phase mRNA Splicing - Major Pathway L1CAM interactions Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis HSF1-dependent transactivation Neurotransmitter Release Cycle CHL1 interactions trans-Golgi Network Vesicle Budding Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APP BCL2 CSNK2B ESR1 FBXO25 FES HAP1 HSF1 HSP90AA1 HSP90AB1 HSPA8 KAT7 LNX1 PLK1 S100A1 S100A2 S100A6 SLC25A4 SMURF2 TRIM27	83 interactors: ABI1 AIPL1 ALDOB APOB BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCAR2 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DNAJC7 DPP3 DYNLL1 EGFR ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTT IL32 JAK2 JUN LALBA MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID RAF1 RB1 REL RGS2 SGTA SNCA SP1 SRRT ST13 STIP1 STMN1 STUB1 SUMO4 TADA3 TCERG1 TCP1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ
Entrez ID		5481	3312
HPRD ID		11875	07205
Ensembl ID		ENSG00000171497	ENSG00000109971
Uniprot IDs		E5KN55 Q08752	P11142 Q53HF2
PDB IDs			3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4HWI
Enriched GO Terms of Interacting Partners?		Axonogenesis Regulation Of Cellular Response To Heat Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Response To Heat Neuron Development Cellular Protein Metabolic Process Axon Guidance Cell Morphogenesis Neuron Differentiation Generation Of Neurons Regulation Of Binding Response To Heat Negative Regulation Of Cellular Metabolic Process Neurogenesis Nervous System Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Binding Cell Development Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Chemotaxis Protein Modification By Small Protein Conjugation Protein Metabolic Process Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Movement Of Cell Or Subcellular Component Cellular Response To Stimulus Positive Regulation Of Cell Cycle Phase Transition Response To Temperature Stimulus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of Calcium Ion Transport Intracellular Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Innate Immune Response	Regulation Of Cell Death Protein Folding Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Protein Refolding Response To Stress Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Organic Substance Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Abiotic Stimulus Protein Metabolic Process Regulation Of Protein Stability Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signaling Defense Response Chaperone Cofactor-dependent Protein Refolding Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Signal Transduction Cell Communication Cellular Response To Organic Substance Protein Complex Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		accurately blastx classifications close cog degs density differentially downloaded enriched esr1 genecodis gotm gse7429 hundred includes language mapped mineral module modules nrip1 obtain omnibus osteoprotegerin packages searched software vdr	alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi
Tagcloud (Difference) ?		accurately blastx classifications close cog degs density differentially downloaded enriched esr1 genecodis gotm gse7429 hundred includes language mapped mineral module modules nrip1 obtain omnibus osteoprotegerin packages searched software vdr	alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi
Tagcloud (Intersection) ?