SAPCD2 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SAPCD2	GMNN
Description		suppressor APC domain containing 2	geminin DNA replication inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Apical Junction Complex Apical Cortex Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Protein Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Positive Regulation Of Cell Population Proliferation Cell Division Regulation Of Establishment Of Planar Polarity Symmetric Cell Division Negative Regulation Of Protein Localization To Cell Cortex	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways			Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Platelet count ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: AIRIM ATF4 BFSP2 CYSRT1 EXOC7 GMNN GPRASP2 KRT3 KRTAP1-3 MDFI RALBP1 USHBP1 VCL	34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		89958	51053
HPRD ID		12943	06783
Ensembl ID		ENSG00000186193	ENSG00000112312
Uniprot IDs		Q86UD0	O75496
PDB IDs			1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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