IFT172

Description		intraflagellar transport 172
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GO Annotations	Cellular Component	Cilium Axoneme Intraciliary Transport Particle Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip Sperm Cytoplasmic Droplet Extracellular Vesicle
	Molecular Function
	Biological Process	Neural Tube Formation Neural Tube Closure Heart Looping Notch Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Heart Development Epidermis Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Negative Regulation Of Keratinocyte Proliferation Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Development Cytoplasmic Microtubule Organization Intraciliary Anterograde Transport Intraciliary Transport Keratinocyte Proliferation Cilium Organization Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Limb Development Cilium Assembly Bone Development Hindgut Development Left/right Axis Specification Non-motile Cilium Assembly
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Calcium levels ( 20705733) Chronic kidney disease ( 20383146) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Total cholesterol levels ( 30718733)
Novel Interacting Genes		4 novel interacting genes: DNAJC27 EFR3B RAB10 TMEM214
Interacting Genes		3 interacting genes: LCOR LHX3 LHX4
Entrez ID		26160
HPRD ID		09576
Ensembl ID		ENSG00000138002
Uniprot IDs		A0A6Q8PGJ2 Q9UG01
PDB IDs		9H2D
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Cell Differentiation In Spinal Cord Placenta Development Ventral Spinal Cord Interneuron Specification Prolactin Secreting Cell Differentiation Somatotropin Secreting Cell Differentiation Protein Localization To Basolateral Plasma Membrane Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Thyroid-stimulating Hormone-secreting Cell Differentiation Protein Localization To Plasma Membrane Insulin-responsive Compartment Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Protein Localization To Cell Periphery Secretory Vesicle
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