FDX1L and LHX4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FDX1L	LHX4
Gene Name		ferredoxin 1-like	LIM homeobox 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Nucleus
	Molecular Function	Electron Carrier Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	C21-steroid Hormone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Sterol Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Placenta Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Motor Neuron Axon Guidance Organ Morphogenesis Medial Motor Column Neuron Differentiation Negative Regulation Of Apoptotic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP LHX4	12 interactors: CHCHD2 FDX1L IFT172 ISL1 LDB2 LONRF1 ORC6 SH2D1A SNRNP25 SSX1 TXNDC5 USP2
Entrez ID		112812	89884
HPRD ID		14465	03686
Ensembl ID		ENSG00000267673
Uniprot IDs		Q6P4F2 Q8N8B8	Q969G2
PDB IDs		2Y5C
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Medial Motor Column Neuron Differentiation Collateral Sprouting In Absence Of Injury Axon Guidance Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axonogenesis Axon Choice Point Recognition Axon Development Somatic Motor Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Remodeling Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Copper Ion Homeostasis Neuron Development Central Nervous System Development Copper Ion Homeostasis Suckling Behavior Cell Morphogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Differentiation Cell Projection Organization Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Motor Neuron Axon Guidance Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Reproductive Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Spinal Cord Motor Neuron Differentiation Regulation Of Cell Cycle G2/M Phase Transition Movement Of Cell Or Subcellular Component Axon Cargo Transport Mating Neuromuscular Junction Development Generation Of Neurons Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition	Spinal Cord Motor Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord
Tagcloud ?			add besides clinician concern congenital correct costly deviation disturb emphasis genetics ghr ghrhr height hesx1 hypothalamus igfr know lhx3 manifestation normality nutrition ones origins pituitary pou1f1 prop1 psychosocial stature
Tagcloud (Difference) ?			add besides clinician concern congenital correct costly deviation disturb emphasis genetics ghr ghrhr height hesx1 hypothalamus igfr know lhx3 manifestation normality nutrition ones origins pituitary pou1f1 prop1 psychosocial stature
Tagcloud (Intersection) ?