SMARCC1 and SLC15A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMARCC1	SLC15A2
Description		SWI/SNF related BAF chromatin remodeling complex subunit C1	solute carrier family 15 member 2
Image
GO Annotations	Cellular Component	Kinetochore Chromatin Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Cytoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex	Plasma Membrane Membrane Apical Plasma Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding	Protein Binding Symporter Activity Peptide:proton Symporter Activity Transmembrane Transporter Activity Oligopeptide Transmembrane Transporter Activity Tripeptide Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Regulation Of Mitotic Metaphase/anaphase Transition Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Immune System Process Oligopeptide Transport Protein Transport Peptide Transport Peptidoglycan Transport Xenobiotic Transport Dipeptide Transport Innate Immune Response Transmembrane Transport Renal Absorption Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Dipeptide Import Across Plasma Membrane Tripeptide Import Across Plasma Membrane Antibacterial Innate Immune Response Transport Across Blood-brain Barrier Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs			Ampicillin Cefotaxime Oxacillin Benzylpenicillin
Diseases
GWAS		Age at first birth ( 34211149) Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		53 interacting genes: ADAMTSL4 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 SREBF1 TAF15 TRIM42 UFSP1 USP7 VGLL3 ZNF581	26 interacting genes: ADAM12 ANKS1A AQP1 C11orf87 CHRD ENKD1 KLHL38 KPRP KRT34 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP6-3 LMO4 NHERF4 NTAQ1 OTX1 PDZK1 PITX1 PLSCR4 SMARCC1 TENT5B TLX3 VENTX WWOX
Entrez ID		6599	6565
HPRD ID		03435	09088
Ensembl ID		ENSG00000173473	ENSG00000163406
Uniprot IDs		Q58EY4 Q92922	Q16348
PDB IDs		2YUS 5GJK 6KZ7 6YXO 6YXP	6EZI 7PMY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Transcription Coregulator Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Cellular Response To Hormone Stimulus Rhythmic Process Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Factor Activity Protein-DNA Complex Disassembly Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Ketone Identical Protein Binding Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Nuclear Receptor-mediated Corticosteroid Signaling Pathway DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament Cellular Response To Peptide Hormone Stimulus Regulation Of Primary Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Alpha-beta T Cell Activation Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Innate Immune Response Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Defense Response Regulation Of Signal Transduction By P53 Class Mediator Protein K29-linked Ubiquitination Progesterone Receptor Signaling Pathway Response To Hormone Transcription Coregulator Activity	Intermediate Filament Brush Border
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