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UBA7 and ISG15
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
HPRD
(two hybrid, in vivo)
UBA7
ISG15
Description
ubiquitin like modifier activating enzyme 7
ISG15 ubiquitin like modifier
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Modifier Activating Enzyme Activity
Ligase Activity
ISG15 Activating Enzyme Activity
Integrin Binding
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Biological Process
DNA Damage Response
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
ISG15-protein Conjugation
Innate Immune Response
Immune System Process
Regulation Of Immune System Process
Integrin-mediated Signaling Pathway
Response To Virus
Response To Bacterium
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Positive Regulation Of Bone Mineralization
Negative Regulation Of Protein Ubiquitination
ISG15-protein Conjugation
Positive Regulation Of Protein Oligomerization
Regulation Of Type II Interferon Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-10 Production
Response To Type I Interferon
Defense Response To Bacterium
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Multicellular Organismal Process
Defense Response To Virus
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Protein Localization To Mitochondrion
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Modulation of host responses by IFN-stimulated genes
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Interferon alpha/beta signaling
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
RSV-host interactions
PKR-mediated signaling
Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Extremely high intelligence (
29520040
)
Menarche (age at onset) (
25231870
)
Refractive error (
32231278
)
Regular attendance at a gym or sports club (
29970889
)
Regular attendance at a religious group (
29970889
)
Sleep duration (short sleep) (
30846698
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
21297633
)
Waist circumference adjusted for body mass index (
34021172
)
Blood protein levels (
30072576
)
Interacting Genes
7 interacting genes:
FAS
ISG15
LCOR
RSPH1
UBE2E1
UBE2L3
UBE2L6
25 interacting genes:
BRAP
CBX5
DDOST
FUS
GRPEL1
HDAC6
HIF1A
KLHL26
MRTO4
NAP1L1
NCL
PFN1
RPL23
RPL3
RPN2
SUMO1
TPM3
TPM4
TUBA1B
UBA7
USP14
USP16
USP18
USP21
USP5
Entrez ID
7318
9636
HPRD ID
01873
00958
Ensembl ID
ENSG00000182179
ENSG00000187608
Uniprot IDs
P41226
P05161
PDB IDs
8OIF
8SE9
8SEA
8SEB
8SV8
8WWX
1Z2M
2HJ8
3PHX
3PSE
3R66
3RT3
3SDL
5TL6
5W8T
5W8U
6BI8
6FFA
6XA9
7RBS
7S6P
8OIF
8SE9
8SEA
8SEB
8SV8
Enriched GO Terms of Interacting Partners
?
ISG15-protein Conjugation
Ubiquitin Conjugating Enzyme Activity
ISG15 Transferase Activity
Ubiquitin-like Protein Transferase Activity
Modification-dependent Protein Catabolic Process
Protein Ubiquitination
Ubiquitin-protein Transferase Activity
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
Post-translational Protein Modification
Macromolecule Catabolic Process
Fas Signaling Pathway
Ubiquitin Ligase Complex
Proteolysis
Radial Spoke Head 1
Radial Spoke Head 3
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Oligomerization
Cellular Response To Hyperoxia
Radial Spoke Head
CD95 Death-inducing Signaling Complex
Death-inducing Signaling Complex
Activation-induced Cell Death Of T Cells
Outer Dense Fiber
Regulation Of Protein Ubiquitination
Necroptotic Signaling Pathway
Protein Modification Process
Ubiquitin-protein Transferase Activator Activity
Cysteine-type Deubiquitinase Activity
Protein Deubiquitination
Regulation Of Protein Stability
Protein Modification By Small Protein Removal
Cysteine-type Peptidase Activity
Protein Metabolic Process
Post-translational Protein Modification
Protein Modification Process
Presynaptic Cytosol
Muscle Thin Filament Tropomyosin
Oligosaccharyltransferase Complex B
Macromolecule Metabolic Process
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Proteolysis
Ubiquitin Protein Ligase Binding
Oligosaccharyltransferase Complex A
Cytoplasm
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Cysteine-type Endopeptidase Activity
Regulation Of Epithelial Cell Migration
Oligosaccharyltransferase Complex
Negative Regulation Of Catabolic Process
Axonal Transport Of Mitochondrion
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Proteolysis
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Nucleolus
Peptidase Activity
Ubiquitin Binding
Cellular Response To Interleukin-4
Deubiquitinase Activity
Protein K48-linked Deubiquitination
Mitochondrion Transport Along Microtubule
Response To Interleukin-4
Postsynaptic Cytosol
Histone Deacetylase Binding
Response To Cytokine
RNA Binding
Regulation Of Protein Metabolic Process
Establishment Of Mitochondrion Localization
Response To Peptide
Proteolysis
Positive Regulation Of Gene Expression
Negative Regulation Of Protein Metabolic Process
ISG15 Activating Enzyme Activity
Polyubiquitinated Misfolded Protein Transport
Positive Regulation Of Cholangiocyte Proliferation
Positive Regulation Of Ribosome Biogenesis
Hsp90 Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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