GLS and ARL6

		GLS	ARL6
Description		glutaminase	ARF like GTPase 6
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Synapse	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Membrane Coat Cell Projection Extracellular Exosome
	Molecular Function	Glutaminase Activity Protein Binding Hydrolase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Suckling Behavior Regulation Of Respiratory Gaseous Exchange By Nervous System Process Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Chemical Synaptic Transmission Protein Homotetramerization Intracellular Glutamate Homeostasis	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Protein Transport Wnt Signaling Pathway Vesicle-mediated Transport Cell Projection Organization Melanosome Transport Fat Cell Differentiation Protein Polymerization Cilium Assembly Protein Localization To Cilium Protein Localization To Non-motile Cilium Protein Transport From Ciliary Membrane To Plasma Membrane
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	BBSome-mediated cargo-targeting to cilium
Drugs		Glutamic acid
Diseases			Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) JT interval (sulfonylurea treatment interaction) ( 27958378) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Male infertility ( 19478329)
Interacting Genes		7 interacting genes: ATXN10 CDC42 OGT PARD6A RSPH1 SNTA1 TAX1BP3	6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B
Entrez ID		2744	84100
HPRD ID		00700	10588
Ensembl ID		ENSG00000115419	ENSG00000113966
Uniprot IDs		H7C201 O94925	Q9H0F7
PDB IDs		3CZD 3UNW 3UO9 3VOY 3VOZ 3VP0 3VP1 3VP2 3VP3 3VP4 4O7D 5D3O 5FI2 5FI6 5FI7 5HL1 5I94 5JYO 5JYP 5U0I 5U0J 5UQE 5WJ6 6LOX 6UJG 6UJM 6UK6 6UKB 6UL9 6ULA 6ULJ 6UMC 6UMD 6UME 6UMF 7REN 7RGG 7SBM 7SBN 8BSK 8BSL 8BSM 8BSN 8GWR 8IMA 8IMB 8JUB 8JUE 8SZJ	2H57
Enriched GO Terms of Interacting Partners?		Cell Projection Cytoskeleton GTP-dependent Protein Binding Wnt Signaling Pathway Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cytokinesis Cytoplasm GBD Domain Binding Storage Vacuole Endothelin Receptor Signaling Pathway Involved In Heart Process Protein O-acetylglucosaminyltransferase Activity Protein Transport From Ciliary Membrane To Plasma Membrane Axoneme Radial Spoke Head 1 Radial Spoke Head 3 Cell-cell Junction Organization Organelle Organization Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Division Midbody Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neuropilin Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Cellular Component Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Or Maintenance Of Cell Polarity Cytosol Syntrophin Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cilium Positive Regulation Of Protein Localization To Centrosome PAR Polarity Complex Outer Dense Fiber Radial Spoke Head Organelle Assembly Establishment Of Golgi Localization Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Protein-containing Complex	Regulation Of L-glutamate Import Across Plasma Membrane Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Cellular Localization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Organization Negative Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Amine Transport
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