AP3D1 and ARF1

Number of citations of the paper that reports this interaction (PubMedID 11926829)
0

Data Source:
HPRD (in vitro, in vivo)

		AP3D1	ARF1
Description		adaptor related protein complex 3 subunit delta 1	ARF GTPase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Endosome Membrane Membrane Membrane Coat AP-3 Adaptor Complex Axon Terminal Bouton Presynapse Postsynapse Presynaptic Endosome Glutamatergic Synapse Axon Cytoplasm	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Protein Targeting Protein Targeting To Vacuole Intracellular Protein Transport Golgi To Vacuole Transport Lysosomal Transport Anterograde Axonal Transport Protein Transport Vesicle Organization Synaptic Vesicle Budding From Endosome Synaptic Vesicle Coating Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Protein Localization To Organelle Endosome To Melanosome Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Protein Localization To Membrane Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Zinc Ion Import Into Lysosome Melanosome Assembly	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Height ( 28552196 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Monocyte count ( 32888494) Myocardial infarction ( 24916648) Pulse pressure ( 30578418) Red blood cell count ( 27863252 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		13 interacting genes: AP3S1 AP3S2 ARF1 ARF6 CCN2 CDC42 DUX4 FILNC1 GSK3A RUFY1 SLC30A3 VAMP7 VPS41	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		8943	375
HPRD ID		06260	00054
Ensembl ID		ENSG00000065000	ENSG00000143761
Uniprot IDs		A0A8V8TQW4 O14617	P84077
PDB IDs		4AFI 9C58 9C59 9C5B 9C5C	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Intracellular Transport AP-3 Adaptor Complex Vacuolar Transport Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport Golgi Apparatus Golgi Vesicle Transport Vesicle Organization Membrane Organization Protein Transport Membrane Invagination Synaptic Vesicle Coating Intracellular Protein Localization Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Establishment Of Protein Localization Thioesterase Binding Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Organelle Transport Along Microtubule Vesicle Fusion Regulation Of Transport Synaptic Vesicle Recycling Organelle Membrane Fusion Endosomal Vesicle Fusion Regulation Of Endocytosis Anterograde Synaptic Vesicle Transport Early Endosome Melanosome Assembly Golgi To Vacuole Transport Neuron Projection Regulation Of Actin Cytoskeleton Organization Lysosomal Transport Organelle Fusion Regulation Of Actin Filament-based Process Organelle Organization Platelet Dense Granule Organization Regulation Of Supramolecular Fiber Organization Intracellular Membrane-bounded Organelle Endosome Late Endosome Membrane Membrane Fusion Establishment Of Epithelial Cell Polarity Membrane Coat Phagocytosis, Engulfment Positive Regulation Of Transport Vesicle Cargo Loading Dendritic Spine Organization	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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