AP3D1 and VAMP7

Number of citations of the paper that reports this interaction (PubMedID 18775314)
40

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		AP3D1	VAMP7
Description		adaptor related protein complex 3 subunit delta 1	vesicle associated membrane protein 7
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Endosome Membrane Membrane Membrane Coat AP-3 Adaptor Complex Axon Terminal Bouton Presynapse Postsynapse Presynaptic Endosome Glutamatergic Synapse Axon Cytoplasm	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Lamellipodium Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Platelet Alpha Granule Pseudopodium SNARE Complex Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Neuron Projection Synapse Phagocytic Vesicle Extracellular Exosome Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Protein Targeting Protein Targeting To Vacuole Intracellular Protein Transport Golgi To Vacuole Transport Lysosomal Transport Anterograde Axonal Transport Protein Transport Vesicle Organization Synaptic Vesicle Budding From Endosome Synaptic Vesicle Coating Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Protein Localization To Organelle Endosome To Melanosome Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Protein Localization To Membrane Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Zinc Ion Import Into Lysosome Melanosome Assembly	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Phagocytosis, Engulfment Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Autophagosome Maturation Positive Regulation Of Histamine Secretion By Mast Cell
Pathways			trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Interleukin-12 signaling
Drugs
Diseases
GWAS		Height ( 28552196 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Monocyte count ( 32888494) Myocardial infarction ( 24916648) Pulse pressure ( 30578418) Red blood cell count ( 27863252 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: AP3S1 AP3S2 ARF1 ARF6 CCN2 CDC42 DUX4 FILNC1 GSK3A RUFY1 SLC30A3 VAMP7 VPS41	12 interacting genes: AGFG1 ANKRD27 AP3D1 CALM1 DNAJC5 SNAP23 SNAP25 SNAP29 STX1A STX3 STX4 STX7
Entrez ID		8943	6845
HPRD ID		06260	02084
Ensembl ID		ENSG00000065000	ENSG00000124333
Uniprot IDs		A0A8V8TQW4 O14617	P51809
PDB IDs		4AFI 9C58 9C59 9C5B 9C5C	2DMW
Enriched GO Terms of Interacting Partners?		Intracellular Transport AP-3 Adaptor Complex Vacuolar Transport Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport Golgi Apparatus Golgi Vesicle Transport Vesicle Organization Membrane Organization Protein Transport Membrane Invagination Synaptic Vesicle Coating Intracellular Protein Localization Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Establishment Of Protein Localization Thioesterase Binding Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Organelle Transport Along Microtubule Vesicle Fusion Regulation Of Transport Synaptic Vesicle Recycling Organelle Membrane Fusion Endosomal Vesicle Fusion Regulation Of Endocytosis Anterograde Synaptic Vesicle Transport Early Endosome Melanosome Assembly Golgi To Vacuole Transport Neuron Projection Regulation Of Actin Cytoskeleton Organization Lysosomal Transport Organelle Fusion Regulation Of Actin Filament-based Process Organelle Organization Platelet Dense Granule Organization Regulation Of Supramolecular Fiber Organization Intracellular Membrane-bounded Organelle Endosome Late Endosome Membrane Membrane Fusion Establishment Of Epithelial Cell Polarity Membrane Coat Phagocytosis, Engulfment Positive Regulation Of Transport Vesicle Cargo Loading Dendritic Spine Organization	SNAP Receptor Activity SNARE Complex Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport SNARE Binding Membrane Fusion Vesicle-mediated Transport In Synapse Exocytosis Establishment Of Localization In Cell Organelle Localization Synaptic Vesicle Membrane Organization Vesicle Docking Membrane Organization Secretion By Cell Secretion Positive Regulation Of Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Azurophil Granule Long-term Synaptic Potentiation Neuron Projection Protein Transport Specific Granule Synaptic Vesicle Priming Presynapse Establishment Of Protein Localization Neurotransmitter Transport Endomembrane System Synaptic Vesicle Exocytosis Synaptic Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Signal Release Intracellular Transport Intracellular Protein Localization Organelle Organization Syntaxin Binding Regulation Of Synaptic Plasticity Autophagosome Membrane Docking ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Cytoplasmic Vesicle Modulation Of Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Intracellular Protein Transport Endosome To Melanosome Transport
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