AP3D1 and VPS41

Number of citations of the paper that reports this interaction (PubMedID 10559961)
0

Data Source:
HPRD (in vitro, in vivo)

		AP3D1	VPS41
Description		adaptor related protein complex 3 subunit delta 1	VPS41 subunit of HOPS complex
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Endosome Membrane Membrane Membrane Coat AP-3 Adaptor Complex Axon Terminal Bouton Presynapse Postsynapse Presynaptic Endosome Glutamatergic Synapse Axon Cytoplasm	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Cytosol Endosome Membrane Microtubule Cytoskeleton Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Clathrin Complex Lysosomal HOPS Complex
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Targeting Protein Targeting To Vacuole Intracellular Protein Transport Golgi To Vacuole Transport Lysosomal Transport Anterograde Axonal Transport Protein Transport Vesicle Organization Synaptic Vesicle Budding From Endosome Synaptic Vesicle Coating Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Protein Localization To Organelle Endosome To Melanosome Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Protein Localization To Membrane Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Zinc Ion Import Into Lysosome Melanosome Assembly	Protein Targeting To Vacuole Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Cellular Response To Starvation Protein Transport Vesicle-mediated Transport Macroautophagy Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Golgi Vesicle Transport Late Endosome To Lysosome Transport
Pathways			SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Height ( 28552196 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Monocyte count ( 32888494) Myocardial infarction ( 24916648) Pulse pressure ( 30578418) Red blood cell count ( 27863252 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Breast cancer and/or colorectal cancer ( 29698419) Cognitive performance ( 19734545)
Interacting Genes		13 interacting genes: AP3S1 AP3S2 ARF1 ARF6 CCN2 CDC42 DUX4 FILNC1 GSK3A RUFY1 SLC30A3 VAMP7 VPS41	12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B
Entrez ID		8943	27072
HPRD ID		06260	10402
Ensembl ID		ENSG00000065000	ENSG00000006715
Uniprot IDs		A0A8V8TQW4 O14617	P49754
PDB IDs		4AFI 9C58 9C59 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Intracellular Transport AP-3 Adaptor Complex Vacuolar Transport Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport Golgi Apparatus Golgi Vesicle Transport Vesicle Organization Membrane Organization Protein Transport Membrane Invagination Synaptic Vesicle Coating Intracellular Protein Localization Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Establishment Of Protein Localization Thioesterase Binding Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Organelle Transport Along Microtubule Vesicle Fusion Regulation Of Transport Synaptic Vesicle Recycling Organelle Membrane Fusion Endosomal Vesicle Fusion Regulation Of Endocytosis Anterograde Synaptic Vesicle Transport Early Endosome Melanosome Assembly Golgi To Vacuole Transport Neuron Projection Regulation Of Actin Cytoskeleton Organization Lysosomal Transport Organelle Fusion Regulation Of Actin Filament-based Process Organelle Organization Platelet Dense Granule Organization Regulation Of Supramolecular Fiber Organization Intracellular Membrane-bounded Organelle Endosome Late Endosome Membrane Membrane Fusion Establishment Of Epithelial Cell Polarity Membrane Coat Phagocytosis, Engulfment Positive Regulation Of Transport Vesicle Cargo Loading Dendritic Spine Organization	Endosome To Lysosome Transport Vacuolar Transport Early Endosome To Late Endosome Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Vesicle Organization HOPS Complex Endosomal Transport Vesicle-mediated Transport Intracellular Transport Endosome Organization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Lysosome Organization Vacuole Organization Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Intracellular Protein Localization Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Presynaptic Endosome Cytoplasmic Microtubule Organization Microtubule-based Process Axo-dendritic Transport Protein Localization To Vacuole Phagosome-lysosome Fusion Neurotransmitter Receptor Transport Synaptic Vesicle Recycling Protein Localization To Organelle Ubiquitin-like Protein Transferase Activity Lysosomal Membrane Viral Process Negative Regulation Of MiRNA Transcription Viral Release From Host Cell Late Endosome Membrane Organelle Organization Ubiquitin Conjugating Enzyme Activity Transport Along Microtubule Vesicle Budding From Membrane Organelle Localization Lysosome Supramolecular Fiber Organization Protein Targeting Anterograde Axonal Transport Positive Regulation Of Protein Catabolic Process Microtubule-based Transport
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