EIF2B2 and C9orf72

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF2B2	C9orf72
Gene Name		eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	chromosome 9 open reading frame 72
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Autophagic Vacuole Actin Cytoskeleton Cytoplasmic Vesicle Intercellular Bridge
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity	Protein Binding Rab GTPase Binding
	Biological Process	Ovarian Follicle Development Translation Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Myelination Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Endocytosis Autophagy
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 22959728 19734901 20801718) PCA3 expression level ( 23555189)
Protein-Protein Interactions		10 interactors: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1	6 interactors: APP CRX EIF2B2 NMI REL SRPK1
Entrez ID		8892	203228
HPRD ID		05923	12975
Ensembl ID		ENSG00000119718	ENSG00000147894
Uniprot IDs		P49770 Q53XC2	Q96LT7 Q9NUW0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translation In Response To Stress Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Oligodendrocyte Development Regulation Of Cellular Protein Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process Oligodendrocyte Differentiation Negative Regulation Of Translation Glial Cell Development Neurogenesis Response To Heat Cellular Protein Metabolic Process Positive Regulation Of Translational Initiation Response To Glucose Cell Development Positive Regulation Of Hydrolase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Metabolic Process Glial Cell Differentiation Response To Carbohydrate Response To Temperature Stimulus Nervous System Development Protein Metabolic Process Regulation Of Catalytic Activity Translation Gliogenesis Cellular Response To Stress Positive Regulation Of Catalytic Activity Central Nervous System Development Ovarian Follicle Development Axon Guidance Positive Regulation Of Translation Reproduction Regulation Of Gene Expression Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Response To Abiotic Stimulus Cell Differentiation Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress	Gene Expression Defense Response RNA Metabolic Process Positive Regulation Of Photoreceptor Cell Differentiation Response To Stress Synaptic Growth At Neuromuscular Junction Innate Immune Response Collateral Sprouting In Absence Of Injury Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Reproduction Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Regulation Of Gene Expression Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Sperm Chromatin Condensation Rhythmic Process Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Reproductive Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Inflammatory Response Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Viral Genome Replication Copper Ion Homeostasis Suckling Behavior Neurogenesis Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2	990a als amyotrophic arg522arg brainstem causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous tardbp val14met
Tagcloud (Difference) ?		actb aging analysed comprehensive cows deltact differed dominant durations follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold ube2d2	990a als amyotrophic arg522arg brainstem causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous tardbp val14met
Tagcloud (Intersection) ?