C9orf72 and TRIM73

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C9orf72	TRIM73
Description		C9orf72-SMCR8 complex subunit	tripartite motif containing 73
Image			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Membrane Axon Dendrite Growth Cone Cytoplasmic Vesicle Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Cell Projection Neuron Projection Perikaryon Axonal Growth Cone Main Axon Autolysosome Synapse Flemming Body Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol Atg1/ULK1 Kinase Complex	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Regulation Of Protein Localization Stress Granule Assembly Negative Regulation Of Exocytosis Axon Extension Negative Regulation Of Immune Response Autophagosome-lysosome Fusion Regulation Of Synaptic Vesicle Cycle Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly	Innate Immune Response
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19734901 20801718 22959728 24931836 25442119 27455348 29566793 30976013) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)
Interacting Genes		11 interacting genes: APP COIL CRX EIF2B2 HMG20A POP7 REL SRPK1 SYN3 TRIM73 VRTN	18 interacting genes: ARID5A BEX2 C9orf72 DDIT4L FHL2 GNG3 HGS KRT34 NTAQ1 OIP5 PNMA1 POU6F2 PRR35 PSMF1 RUSC1 TASOR2 TTC23 YPEL3
Entrez ID		203228	375593
HPRD ID		12975	18606
Ensembl ID		ENSG00000147894	ENSG00000178809
Uniprot IDs		Q96LT7	Q86UV7
PDB IDs		6LT0 6V4U 7MGE 7O2W
Enriched GO Terms of Interacting Partners?
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